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文件

Y0000838

多塞平盐酸盐

Name: 多塞平 盐酸盐
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

经验公式（希尔记法）:

C₁₉H₂₁NO · HCl

CAS号:

1229-29-4

分子量:

315.84

MDL编号:

MFCD00079135

PubChem化学物质编号:

329831184

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

doxepin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

InChI key

MHNSPTUQQIYJOT-SJDTYFKWSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Doxepin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

Y0000851

多塞平, European Pharmacopoeia (EP) Reference Standard

1225511

1225500

多塞平盐酸盐, United States Pharmacopeia (USP) Reference Standard

1225522

1225533

PHR8924

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P264 - P270 - P301 + P310 + P330 - P405 - P501

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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索取COA

Novel therapeutic usage of low-dose doxepin hydrochloride.

Haramandeep Singh et al.

Expert opinion on investigational drugs, 16(8), 1295-1305 (2007-08-10)

Low-dose doxepin hydrochloride (1, 3 and 6 mg) is a tricyclic antidepressant currently being investigated for the treatment of primary insomnia in adult and geriatric patients. Although it has been used at much higher doses to treat depression effectively for

Anti-inflammatory effects of doxepin hydrochloride against LPS-induced C6-glioma cell inflammatory reaction by PI3K-mediated Akt signaling.

Feng Tao et al.

Journal of biochemical and molecular toxicology, 34(2), e22424-e22424 (2019-11-20)

Recent studies have shown that tricyclic antidepressants (TCAs) may have anti-inflammatory and anticonvulsant effects in addition to its antidepressant effects. So far, the nonantidepressant effects of TCAs and their molecular pharmacological mechanisms remain completely unclear. Chronic inflammation in the brain

Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.

Grzegorz Jagla et al.

Pharmacological reports : PR, 66(3), 459-465 (2014-06-07)

The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been proposed, but there

Transbuccal delivery of doxepin: studies on permeation and histological investigation.

Alvaro Gimeno et al.

International journal of pharmaceutics, 477(1-2), 650-654 (2014-12-03)

According to previous studies reporting the anesthetic/analgesic action of oral topical doxepin administration, this study evaluated a model of buccal permeation to determine the depth of delivery of doxepin into excised porcine buccal mucosa following topical application of a saturated

Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.

Shigeru Hishinuma et al.

Biochemical pharmacology, 91(2), 231-241 (2014-07-30)

Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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多塞平 盐酸盐