Y0001181
奥芬那君 盐酸盐
European Pharmacopoeia (EP) Reference Standard
别名:
β-二甲基氨基乙基-2-甲基二苯甲醚 盐酸盐, N,N-二甲基-2-(2-甲基二苯甲基氧基)乙胺 盐酸盐, 邻甲苯海明 盐酸盐
等级
pharmaceutical primary standard
API类
orphenadrine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
Cl.CN(C)CCOC(c1ccccc1)c2ccccc2C
InChI
1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H
InChI key
UQZKYYIKWZOKKD-UHFFFAOYSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Orphenadrine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
毒蕈碱型受体拮抗剂；H1 组胺受体拮抗剂；肌肉松弛剂。据报道，奥芬那君还可抑制去甲肾上素转运蛋白并且阻塞 NMDA 受体离子通道。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mei-juan Xu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(7), 730-734 (2007-09-22)
To study the enzyme kinetics of schizandrin metabolism in different gender in rat liver microsomes, liver microsomes were prepared from male or female rats. Schizandrin was incubated with rat liver microsomes. Schizandrin and its metabolites were isolated and identified by
Lawan Sratthaphut et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127(10), 1723-1729 (2007-10-06)
The estimation of paracetamol and orphenadrine citrate in a multicomponent pharmaceutical dosage form by spectrophotometric method has been reported. Because of highly interference in the spectra and the presence of non-linearity caused by the analyte concentrations which deviate from Beer
Mirosław Czuczwar et al.
Pharmacological reports : PR, 61(4), 732-736 (2009-10-10)
Orphenadrine is an anticholinergic drug used in the treatment of Parkinson's disease, and is also known to exert nonspecific antagonistic activity at the phencyclidine binding site of the N-methyl-D-aspartate (NMDA) receptor. The aim of this study was to assess the
M Elghazali et al.
Research in veterinary science, 85(3), 563-569 (2008-03-07)
The pharmacokinetics of orphenadrine (ORPH) following a single intravenous (i.v.) dose was investigated in six camels (Camelus dormedarius). Orphenadrine was extracted from the plasma using a simple sensitive liquid-liquid extraction method and determined by gas chromatography/mass spectrometry (GC/MS). Following i.v.
[Interaction of drugs with the primary disease - when medicines exacerbate illnesses].
Anne Taegtmeyer et al.
Praxis, 101(6), 363-370 (2012-03-16)
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