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文件

Y0001503

Quinapril for system suitability

Name: Quinapril for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

Quinapril hydrochloride, (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride

经验公式（希尔记法）:

C₂₅H₃₀N₂O₅ · HCl

CAS号:

82586-55-8

分子量:

474.98

MDL编号:

MFCD00889215

PubChem化学物质编号:

329831462

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

quinapril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(O)=O

InChI

1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1

InChI key

IBBLRJGOOANPTQ-JKVLGAQCSA-N

Gene Information

human ... ACE(1636)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Quinapril for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1593412

1593423

BP1193

Quinapril hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR1944

盐酸喹那普利, Pharmaceutical Secondary Standard; Certified Reference Material

BP010

4-氨基-6-氯苯-1-3-二磺酰胺, British Pharmacopoeia (BP) Reference Standard

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Preclinical toxicology studies with the angiotensin-converting enzyme inhibitor quinapril hydrochloride (Accupril).

E J McGuire et al.

The Journal of toxicological sciences, 21(4), 207-214 (1996-11-01)

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Haruka Nishimuta et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

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