06627
2-氨基吖啶酮
BioReagent, suitable for fluorescence, ≥98.0% (HPLC)
别名:
2-氨基-10H-吖啶-9-酮, 2-氨基-9 (10H)-吖啶酮, 美国医学协会
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关于此项目
经验公式（希尔记法）:
C13H10N2O
化学文摘社编号:
分子量:
210.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Beilstein/REAXYS Number:
172520
product line
BioReagent
Quality Level
assay
≥98.0% (HPLC)
form
powder
mol wt
210.23 g/mol
concentration
≤100%
color
yellow to dark yellow
solubility
DMF: soluble, DMSO: soluble
fluorescence
λex 420 nm; λem 542 nm in 0.1 M Tris pH 8.0
suitability
suitable for fluorescence
InChI
1S/C13H10N2O/c14-8-5-6-12-10(7-8)13(16)9-3-1-2-4-11(9)15-12/h1-7H,14H2,(H,15,16)
InChI key
PIGCSKVALLVWKU-UHFFFAOYSA-N
Application
2-氨基吖啶酮是一种高度荧光芳香化合物，它含有伯胺基，可与碳水化合物的还原端醛基发生反应，被硼氢化钠还原为稳定的胺衍生物(NaBH4)。 可以利用这个荧光团检测聚糖化合物的皮摩尔水平。所得衍生化合物可用反相高效液相色谱法分离，通过正离子电喷雾质谱法MS检测一种强大的荧光疏水探针，在广泛的 pH 范围内性能稳定，适用于聚糖衍生化，结合胶束电动毛细管色谱、反相和正相色谱结合质谱分析来分析复合寡聚糖，从而测定个别低聚糖的相对浓度和结构同一性。λ激发和λ发射分别为425 nm和532 nm。
聚糖和糖的荧光标记。
聚糖和糖的荧光标记。高分辨率聚丙烯酰胺凝胶电泳分析荧光标记聚糖 。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yuqing Chang et al.
Analytical biochemistry, 427(1), 91-98 (2012-05-23)
A quantitative and highly sensitive method for the analysis of glycosaminoglycan (GAG)-derived disaccharides that relies on capillary electrophoresis (CE) with laser-induced fluorescence detection is presented. This method enables complete separation of 17 GAG-derived disaccharides in a single run. Unsaturated disaccharides
Wing Lee Chan et al.
PLoS genetics, 14(3), e1007242-e1007242 (2018-03-22)
Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function. To circumvent neonatal lethality of the GorabNull full knockout, Gorab was conditionally inactivated in mesenchymal
Carolyn G Chen et al.
Matrix biology : journal of the International Society for Matrix Biology, 90, 1-19 (2020-02-23)
Hyaluronan plays a key role in regulating inflammation and tumor angiogenesis. Of the three transmembrane hyaluronan synthases, HAS2 is the main pro-angiogenic enzyme responsible for excessive hyaluronan production. We discovered that HAS2 was degraded in vascular endothelial cells via autophagy
Fabio Galeotti et al.
Analytical chemistry, 83(17), 6770-6777 (2011-07-26)
A high-resolution online reverse-phase-high-performance liquid chromatography (RP-HPLC)-fluorescence detector (Fd)-electrospray ionization-mass spectrometry (ESI-MS) separation and structural characterization of disaccharides prepared from heparin (Hep), heparan sulfate (HS), and various low-molecular-weight (LMW)-Hep using heparin lyases and derivatization with 2-aminoacridone (AMAC) are described. A
Yoji Oonuki et al.
Analytical biochemistry, 343(2), 212-222 (2005-07-12)
Various combinations of fluorescent dyes, polyacrylamide gels, and electrophoresis buffers were tested by fluorophore-assisted carbohydrate electrophoresis (FACE) for the purpose of analyzing sulfated and nonsulfated glycosaminoglycan (GAG) oligosaccharides in which disaccharides and low-molecular weight oligosaccharides were included. A nonionic fluorescent
商品
Glycans play a key role in protein structure and disease; representation on cell surfaces is the glycome.
蛋白质的结构修饰对于活细胞是必不可少的。发生调节异常时，它们往往是会引发疾病。聚糖是生物系统中许多结构变异的原因，它们在细胞表面的表现通常被称为“糖”。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 06627-100MG | 04061833276679 |
| 06627-25MG | 04061838646415 |
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