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17783

钙黄绿素-AM

Name: 钙黄绿素-AM
Brand: SIGMA

suitable for fluorescence, BioReagent, ≥90% (HPLC)

别名:

钙黄绿素乙酰氧基甲酯, Calcein O,O′-diacetate tetrakis(acetoxymethyl) ester

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关于此项目

经验公式（希尔记法）:

C₄₆H₄₆N₂O₂₃

化学文摘社编号:

148504-34-1

分子量:

994.86

NACRES:

NA.32

PubChem Substance ID:

57647670

UNSPSC Code:

12171500

MDL number:

MFCD05861516

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product line

BioReagent

Quality Level

100

assay

≥90% (HPLC)

form

solid

mol wt

994.86 g/mol

fluorescence

λ_ex 496 nm; λ_em 516 nm in 0.1 M Tris pH 8.0, esterase; Ca²⁺

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)Cc1c(OC(C)=O)ccc2c1Oc3c(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OC(C)=O)ccc3C24OC(=O)c5ccccc45

InChI

1S/C46H46N2O23/c1-25(49)60-21-64-39(55)17-47(18-40(56)65-22-61-26(2)50)15-32-37(68-29(5)53)13-11-35-43(32)70-44-33(16-48(19-41(57)66-23-62-27(3)51)20-42(58)67-24-63-28(4)52)38(69-30(6)54)14-12-36(44)46(35)34-10-8-7-9-31(34)45(59)71-46/h7-14H,15-24H2,1-6H3

InChI key

XKFSBWQWNMZWFA-UHFFFAOYSA-N

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General description

脂质体含有一种自淬灭荧光染料，称为钙黄绿素。它是一种荧光染料，激发和发射波长分别为495/515 nm。它在浓度高于70mM时发生自淬灭，通常用作脂质囊泡渗漏的指示剂。当捕获的钙黄绿素从脂质体区室泄漏时，可根据荧光增加了计算泄漏速率。它被用作络合物指示剂，用来滴定EDTA螯合的钙离子，并且用于通过荧光检测法测定钙离子浓度。

Application

钙黄绿素-AM已被用于流式细胞术。

钙黄绿素的非荧光细胞渗透衍生物，水解后发出荧光。用作多药耐药蛋白MRP的中性底物；用于肿瘤研究。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sendai virus induced leakage of liposomes containing gangliosides.

Y S Tsao et al.

Biochemistry, 24(5), 1092-1098 (1985-02-26)

Sendai virus induced liposome leakage has been studied by using liposomes containing a self-quenching fluorescent dye, calcein. The liposomes used in this study were prepared by a freeze and thaw method and were composed of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine (1:2.60:1.48

Serum-induced leakage of liposome contents.

T M Allen et al.

Biochimica et biophysica acta, 597(2), 418-426 (1980-04-10)

Efflux of contents from small unilamellar vesicles of various compositions, conaining a highly quenched fluorescent compound (calcein, 175 mM) was determined as a function of temperature in the presence and absence of human serum. Efflux of calcein from the liposomes

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High intrinsic or acquired expression of membrane spanning, adenosine triphosphate binding cassette (ABC) transporter proteins, such as P-glycoprotein (P-gp), in cancers represents a major impediment to chemotherapy, with accelerated drug efflux leading to multi-drug resistance (MDR). Although ABC transporter inhibitors

Graft of the gelatin sponge scaffold containing genetically-modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat with spinal cord transection.

Bao-Ling Du et al.

Journal of biomedical materials research. Part A, 103(4), 1533-1545 (2014-07-22)

Biological materials combined with genetically-modified neural stem cells (NSCs) are candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we performed gelatin sponge (GS) scaffold seeded with neurotrophin-3 (NT-3) and its receptor TrkC gene modifying NSCs

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A promising bone graft substitute is porous titanium. Porous titanium, produced by selective laser melting (SLM), can be made as a completely open porous and load-bearing scaffold that facilitates bone regeneration through osteoconduction. In this study, the bone regenerative capacity

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全球贸易项目编号

货号	GTIN
480835-10G	04061837013041
17783-1MG	04061835183890
17783-5MG	04061838753465

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