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Merck
CN

43819

DL-二硫苏糖醇

≥99.0% (RT)

别名:

1,4-二巯基苏糖醇, DTT, 克莱兰氏试剂

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关于此项目

线性分子式:
HSCH2CH(OH)CH(OH)CH2SH
化学文摘社编号:
3483-12-3
分子量:
154.25
UNSPSC Code:
12352201
NACRES:
NA.21
PubChem Substance ID:
329756409
EC Number:
222-468-7
Beilstein/REAXYS Number:
1719757
MDL number:
MFCD00004877

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产品名称

DL-二硫苏糖醇, ≥99.0% (RT)

SMILES string

O[C@H](CS)[C@H](O)CS

InChI key

VHJLVAABSRFDPM-QWWZWVQMSA-N

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1

assay

≥99.0% (RT)

form

powder

reaction suitability

reagent type: reductant

impurities

≤0.3% 4,5-dihydroxy-1,2-dithiane

mp

40-43 °C
41-44 °C (lit.)

solubility

H2O: 50 mg/mL, clear, colorless
H2O: freely soluble
acetone: freely soluble
chloroform: freely soluble
diethyl ether: freely soluble
ethanol: freely soluble
ethyl acetate: freely soluble

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤250 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

用于将 −SH 基保持在还原态的绝佳试剂；定量还原二硫化物。在 SDS-PAGE 前，DTT 在样品缓冲液中可有效还原蛋白二硫键。DTT 还可用于还原交联剂 N,N′-双(丙烯酰)胱胺的二硫键桥以分解聚丙烯酰胺凝胶基质。DTT 的刺激性和毒性都低于 2-巯基乙醇。通常，使用 DTT (100mM) 所需的浓度是使用 2-巯基乙醇 (5% v/v, 700mM) 的浓度的七分之一。
DL-二硫苏糖醇是组成用于血小板细胞溶胶制备的缓冲液的关键组分。它对于使用胍盐分离RNA以及组织 和细胞均质化也很重要。

Biochem/physiol Actions

DL-二硫苏糖醇通过将二硫键还原为SH基团而使蛋白质变性。它还可以防止蛋白质半胱氨酸残基之间形成分子内和分子间二硫键。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK1099
BCCG5712
BCCM5274
BCCL7020
BCCB7858

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M W Radomski et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(13), 5193-5197 (1990-07-01)
Aggregation of human washed platelets with collagen is accompanied by a concentration-dependent increase in cyclic GMP but not cyclic AMP. NG-Monomethyl-L-arginine (L-MeArg), a selective inhibitor of nitric oxide (NO) synthesis from L-arginine, reduces this increase and enhances aggregation. L-Arginine, which
R G Knowles et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(13), 5159-5162 (1989-07-01)
A soluble enzyme obtained from rat forebrain catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L-arginine. The NO formed stimulates the soluble guanylate cyclase and this stimulation is abolished by low concentrations of hemoglobin. The synthesis of
M B Donati et al.
Cancer research, 46(12 Pt 1), 6471-6474 (1986-12-01)
It has repeatedly been proposed that fibrin plays a role in tumor growth and metastasis. Among tumor cell products or activities which may promote clot formation, cancer procoagulant (CP), a direct activator of coagulation factor X, has been suggested to
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Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), a dithiol that
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We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
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