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46955

荧光素

Name: 荧光素
Brand: SIGMA

free acid

别名:

酸性黄 73

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₂O₅

化学文摘社编号:

2321-07-5

分子量:

332.31

EC Number:

219-031-8

UNSPSC Code:

12171500

NACRES:

NA.32

PubChem Substance ID:

329757275

MDL number:

MFCD00005050

Colour Index Number:

45350

Beilstein/REAXYS Number:

94324

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Quality Level

100

assay

>95.0% (HPLC)

form

powder or crystals

mol wt

332.31 g/mol

concentration

≤100% (2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid)

technique(s)

titration: suitable

color

red

mp

320 °C

solubility

methanol: 0.1 g/10 mL, orange to very deep orange

λ_max

486.0-501.0 nm

fluorescence

λ_ex 490 nm; λ_em 514 nm in 0.1 M Tris pH 8.0

suitability

suitable for fluorescence

SMILES string

Oc1ccc2c(Oc3cc(O)ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H

InChI key

GNBHRKFJIUUOQI-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770), PTPRF(5792)

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General description

荧光素染料是最常用的荧光探针。它可以为上皮缺陷染色，分析角膜上皮的完整性。荧光素用于角膜穿孔的诊断。口服或静脉注射荧光素在荧光素血管造影术中用于检测糖尿病视网膜病变和脉络膜新生血管膜。

Application

荧光素已用于：

Caco-2电池的渗透性检测
用于测试终生荧光标准品的适用性
作为荧光团，用于在存在血红蛋白时迅速恢复荧光峰值和荧光浓度
在氧自由基吸收能力(ORAC)检测中作为荧光探针

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ocular health assessment

Prokopich CL, et al.

Clinical Pediatric Nephrology, Second Edition, 221-318 (2007)

Absorption and fluorescence properties of fluorescein

Sjoback R, et al.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 51(6), L7-L21 (1995)

Diagnostic agents

Robert-Gnansia E

Drugs During Pregnancy and Lactation, 502-513 (2007)

Microfluidic gut-on-a-chip with three-dimensional villi structure

Shim KY, et al.

Biomedical Microdevices, 19(2), 37-37 (2017)

Autoantigen BiP-Derived HLA-DR4 Epitopes Differentially Recognized by Effector and Regulatory T Cells in Rheumatoid Arthritis.

Hirofumi Shoda et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(5), 1171-1181 (2015-03-18)

The balance between effector and regulatory CD4+ T cells plays a key role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine whether the RA autoantigen BiP has epitopes for both effector and regulatory

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全球贸易项目编号

货号	GTIN
46955-100G-F	04061832358987
46955-250MG-F	04061832532134
46955-500G-F	04061832358994
46955-1G-F	04061823354134

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