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透明质酸钠盐来源于马链球菌

Name: 透明质酸 钠盐 来源于<I>马链球菌</I>
Brand: SIGMA

bacterial glycosaminoglycan polysaccharide

别名:

聚（β-葡萄糖醛酸-[1→3]-β-N-乙酰葡糖胺-[1→4]），交替

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关于此项目

化学文摘社编号:

9067-32-7

MDL number:

MFCD00875848

UNSPSC Code:

51202002

PubChem Substance ID:

24878223

NACRES:

NA.25

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biological source

(Streptococcus equi)

Quality Level

200

form

powder or crystals

mol wt

~1.5-1.8 x 10E6 Da

impurities

≤1% protein

color

white

solubility

H₂O: 5 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

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General description

透明质酸（HA）是中枢神经系统细胞外基质的重要组分，是在所有脊椎动物结缔组织中都能发现的多功能大分子。这种超分子糖胺聚糖是一种聚阴离子天然聚合物，以线性多糖的形式存在。它由葡萄糖醛酸和N-乙酰氨基葡萄糖通过β-1,4键重复组成。透明质酸在眼睛、关节和心脏瓣膜中大量存在。

Application

马链球菌透明质酸钠盐已用于：

与甲基丙烯酸酐合成交联甲基丙烯酸 HA 水凝胶（Coll-MeHA）
在磷酸盐缓冲盐水（PBS）中取代 PBS 浴槽来改变润滑剂成分
制备润滑剂，以研究对人体骨关节炎（OA）软骨边界润滑的影响

Biochem/physiol Actions

透明质酸（HA）是滑膜液和关节软骨的重要组分，起边界润滑剂的作用。它具有多种物理化学性质，包括生物可降解性、生物相容性、无毒性和非免疫原性。透明质酸被认为是生物医学用途的重要工具，如药物输送、组织工程、整形外科、眼科手术和骨关节炎手术。它参与身体缓冲和润滑。这种强大的抗氧化剂可以将水与组织结合。

Other Notes

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000431155

0000464558

BCCN0155

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Effects of hyaluronic acid and γ-globulin concentrations on the frictional response of human osteoarthritic articular cartilage.

Jae-Yong Park et al.

PloS one, 9(11), e112684-e112684 (2014-11-27)

Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and

Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions.

Telma E Santos et al.

Cell reports, 32(3), 107907-107907 (2020-07-23)

During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth

Increased vasculogenesis of endothelial cells in hyaluronic acid augmented fibrin-based natural hydrogels - from in vitro to in vivo models.

H C Lin et al.

European cells & materials, 40, 133-145 (2020-09-21)

Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various

Oxidized Hyaluronic Acid Hydrogels as a Carrier for Constant-Release Clenbuterol Against High-Fat Diet-Induced Obesity in Mice.

Wei-Yao Chen et al.

Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)

The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use

Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke.

Tao Jin et al.

Biomaterials, 113, 176-190 (2016-11-07)

Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics

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Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

糖胺聚糖和蛋白多糖

有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。

Pharmaceutical Research Applications of Carbohydrates and Polysaccharides

Discover the role of carbohydrates in drug delivery, from solubility and stability improvement to advanced controlled-release systems.

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全球贸易项目编号

货号	GTIN
561452-4X25ML	04061837888564
561452-100ML	04061837888557
53747-10G	04061832565699
53747-1G	04061835365784

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主要文件

透明质酸钠盐来源于马链球菌

bacterial glycosaminoglycan polysaccharide

选择尺寸

关于此项目

属性

biological source

Quality Level

form

mol wt

impurities

color

solubility

storage temp.

SMILES string

InChI

InChI key

相关类别

说明

General description

Application

Biochem/physiol Actions

Other Notes

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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主要文件

透明质酸 钠盐 来源于马链球菌

bacterial glycosaminoglycan polysaccharide

选择尺寸

关于此项目

属性

biological source

Quality Level

form

mol wt

impurities

color

solubility

storage temp.

SMILES string

InChI

InChI key

相关类别

说明

General description

Application

Biochem/physiol Actions

Other Notes

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

已有该产品？

同行评审论文

技术文章和实验方案

商品

相关内容

全球贸易项目编号

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透明质酸钠盐来源于马链球菌