74137
D-手性-肌醇
≥98.0% (HPLC)
别名:
D-(+)-手性肌醇, 1,2,4/3,5,6-六羟基环己烷
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关于此项目
经验公式（希尔记法）:
C6H12O6
化学文摘社编号:
分子量:
180.16
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
EC Number:
211-394-0
MDL number:
InChI key
CDAISMWEOUEBRE-LKPKBOIGSA-N
InChI
1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4-,5+,6+/m0/s1
SMILES string
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
assay
≥98.0% (HPLC)
form
solid
optical activity
[α]/D 64.0±3.0°, c = 1 in H2O
color
white
mp
230 °C (lit.)
storage temp.
2-8°C
Quality Level
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Application
- D-手性肌醇在临床实践中的应用：肌醇基础和临床研究专家组的广泛综述介绍了D-手性肌醇作为管理多囊卵巢综合征等疾病的宝贵物质，突出了其在代谢综合征管理中的临床应用和潜在益处（Dinicola等人，2024年）。
- D-手性肌醇增强寿命和抗氧化能力：一项研究表明，D-手性肌醇通过激活Nrf-2/SKN-1和FOXO/DAF-16途径来增强秀丽隐杆线虫的抗氧化能力并延长其寿命，表明其在优化与年龄相关的健康干预措施中的剂量的潜力（Shi等人，2023年）。
Biochem/physiol Actions
胰岛素信号转导中的重要第二信使。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hao-Han Chang et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 8-14 (2014-07-26)
Diabetic nephropathy is a serious complication of diabetes mellitus with a pressing need for effective metabolic markers to detect renal impairment. Of potential significance are the inositol compounds, myo-inositol (MI), and the less abundant stereoisomer, D-chiro-inositol (DCI), which are excreted
J E Nestler et al.
The New England journal of medicine, 340(17), 1314-1320 (1999-04-29)
Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration of D-chiro-inositol would replenish stores of the mediator and
Alessandro D Genazzani et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(6), 438-443 (2014-03-08)
Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate
Ken-ichi Yoshida et al.
Applied and environmental microbiology, 72(2), 1310-1315 (2006-02-08)
D-chiro-inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation. Here, we report genetic modification of Bacillus subtilis
Alfonsa Pizzo et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(3), 205-208 (2013-12-20)
Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous
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