74137
D-手性-肌醇
≥98.0% (HPLC)
别名:
D-(+)-手性肌醇, 1,2,4/3,5,6-六羟基环己烷
质量水平
方案
≥98.0% (HPLC)
表单
solid
旋光性
[α]/D 64.0±3.0°, c = 1 in H2O
颜色
white
mp
230 °C (lit.)
储存温度
2-8°C
SMILES字符串
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
InChI
1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4-,5+,6+/m0/s1
InChI key
CDAISMWEOUEBRE-LKPKBOIGSA-N
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应用
- D-手性肌醇在临床实践中的应用：肌醇基础和临床研究专家组的广泛综述介绍了D-手性肌醇作为管理多囊卵巢综合征等疾病的宝贵物质，突出了其在代谢综合征管理中的临床应用和潜在益处（Dinicola等人，2024年）。
- D-手性肌醇增强寿命和抗氧化能力：一项研究表明，D-手性肌醇通过激活Nrf-2/SKN-1和FOXO/DAF-16途径来增强秀丽隐杆线虫的抗氧化能力并延长其寿命，表明其在优化与年龄相关的健康干预措施中的剂量的潜力（Shi等人，2023年）。
生化/生理作用
胰岛素信号转导中的重要第二信使。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ken-ichi Yoshida et al.
Applied and environmental microbiology, 72(2), 1310-1315 (2006-02-08)
D-chiro-inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation. Here, we report genetic modification of Bacillus subtilis
J E Nestler et al.
The New England journal of medicine, 340(17), 1314-1320 (1999-04-29)
Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration of D-chiro-inositol would replenish stores of the mediator and
Hao-Han Chang et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 8-14 (2014-07-26)
Diabetic nephropathy is a serious complication of diabetes mellitus with a pressing need for effective metabolic markers to detect renal impairment. Of potential significance are the inositol compounds, myo-inositol (MI), and the less abundant stereoisomer, D-chiro-inositol (DCI), which are excreted
Alessandro D Genazzani et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(6), 438-443 (2014-03-08)
Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate
Alfonsa Pizzo et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(3), 205-208 (2013-12-20)
Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous
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