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93851

DL-o-Tyrosine

Name: <SC>DL</SC>-<I>o</I>-Tyrosine
Brand: SIGMA

≥96.0% (NT), suitable for HPLC

别名:

(±)-2-Amino-3-(2-hydroxyphenyl)propionic acid, 3-(2-Hydroxyphenyl)-DL-alanine

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关于此项目

经验公式（希尔记法）:

C₉H₁₁NO₃

化学文摘社编号:

2370-61-8

分子量:

181.19

NACRES:

NA.26

PubChem Substance ID:

329770279

UNSPSC Code:

12352209

EC Number:

219-134-8

MDL number:

MFCD00021725

Beilstein/REAXYS Number:

2805789

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产品名称

DL-o-Tyrosine, ≥96.0% (NT)

assay

≥96.0% (NT)

form

powder

technique(s)

HPLC: suitable

color

white to faint brown

application(s)

peptide synthesis

SMILES string

NC(Cc1ccccc1O)C(O)=O

InChI

1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13)

InChI key

WRFPVMFCRNYQNR-UHFFFAOYSA-N

Biochem/physiol Actions

ortho-Tyrosine (o-Tyrosine), an isomer of standard p-tyrosine, is a phenylalanine oxidation product used as an amino acid oxidation stress marker in analytical procedures such as HPLC and LC-ESI-MS/MS.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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LC-ESI-MS/MS method for oxidative stress multimarker screening in the exhaled breath condensate of asbestosis/silicosis patients.

K Syslová et al.

Journal of breath research, 4(1), 017104-017104 (2010-01-07)

The sensitive assay method was developed for a parallel, rapid and precise determination of the most prominent oxidative stress biomarkers: 8-iso-prostaglandin F(2α) a lipid oxidation biomarker, o-tyrosine an amino acid oxidation biomarker and 8-hydroxy-2'-deoxy-guanosine a nucleic acid oxidation biomarker. The

Proteins containing oxidized amino acids induce apoptosis in human monocytes.

Rachael A Dunlop et al.

The Biochemical journal, 435(1), 207-216 (2011-01-08)

Cellular deposits of oxidized and aggregated proteins are hallmarks of a variety of age-related disorders, but whether such proteins contribute to pathology is not well understood. We previously reported that oxidized proteins form lipofuscin/ceroid-like bodies with a lysosomal-type distribution and

Measurement of o- and m-tyrosine as markers of oxidative damage in motor neuron disease.

A Poljak et al.

Redox report : communications in free radical research, 5(2-3), 137-140 (2000-08-12)

Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage, and antioxidant reserve.

C H Magsino et al.

Metabolism: clinical and experimental, 49(6), 799-803 (2000-07-06)

We have examined the effect of short-term triiodothyronine (T3) administration on reactive oxygen species (ROS) generation by leukocytes in 9 euthyroid subjects. At a dose of 60 microg/d orally for 7 days, T3 induced a significant increase in ROS generation

Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids.

P Dandona et al.

Circulation, 101(2), 122-124 (2000-01-19)

The purpose of this study was to test whether carvedilol has an antioxidant effect in humans in vivo. We administered 3.125 mg of carvedilol twice daily to normal subjects for 1 week. ROS generation by polymorphonuclear leukocytes and mononuclear cells

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货号	GTIN
93851-100MG	04061832720357

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