A0885
金精三羧酸 铵盐
powder
别名:
ATA, 亚氨基三羧酸铵, 铝试剂
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关于此项目
线性分子式:
C22H14O9 · 3NH3
化学文摘社编号:
分子量:
473.43
EC Number:
209-319-1
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
MDL number:
Colour Index Number:
43810
Beilstein/REAXYS Number:
3900820
InChI key
AIPNSHNRCQOTRI-UHFFFAOYSA-N
InChI
1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3
SMILES string
N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O
biological source
synthetic
form
powder
color
dark red
mp
220-225 °C (dec.) (lit.)
solubility
water: soluble 100 mg/mL, dark red
λmax
552 nm (λmax: )
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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Application
金精三羧酸铵盐已被用作核酸酶抑制剂来研究其对转染的影响。
Biochem/physiol Actions
金精三羧酸易于在水溶液中聚合，形成稳定的自由基，抑制蛋白质-核酸相互作用。它通过阻止核酸与酶的结合而成为核糖核酸酶和拓扑异构酶 II 的有效抑制剂。它刺激酪氨酸磷酸化过程，包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 途径，神经母细胞瘤细胞中的 ErbB4，以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 C。金精三羧酸抑制许多细胞类型的细胞凋亡。其神经保护作用，可能是由于其能够阻止 Ca2+ 不可渗透的 GluR2 受体的下调或其抑制钙蛋白酶的能力，钙蛋白酶是一种在凋亡过程中被激活的 Ca2+ 激活的蛋白酶。
Other Notes
可能含有大量的聚合物材料。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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