A1106
抗-ATM抗体，小鼠单克隆
clone MAT3-4G10/8, purified from hybridoma cell culture
别名:
抗共济失调毛细血管扩张突变
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关于此项目
Conjugate:
unconjugated
Clone:
MAT3-4G10/8, monoclonal
Application:
immunoprecipitation (IP)
indirect ELISA
western blot
indirect ELISA
western blot
Species reactivity:
human, mouse
Citations:
41
Technique(s):
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
Uniprot accession no.:
产品名称
抗-ATM抗体，小鼠单克隆, clone MAT3-4G10/8, purified from hybridoma cell culture
biological source
mouse
recombinant
expressed in mouse cell line
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
MAT3-4G10/8, monoclonal
form
PBS solution
mol wt
antigen ~300 kDa
species reactivity
human, mouse
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ATM(472)
mouse ... Atm(11920)
General description
单克隆抗ATM（小鼠IgG1同种型）源自通过小鼠骨髓瘤细胞（NSO）融合产生的杂交瘤MAT3-4G10/8和用肽免疫的BALB/c小鼠脾细胞。
Immunogen
跨越小鼠ATM的1967-1988位的肽，在其NH2末端含有与KLH偶联的半胱氨酸。
Application
ATM单克隆抗体可用于免疫印迹、ELISA和免疫沉淀。
Biochem/physiol Actions
单克隆抗ATM抗体与小鼠和人ATM发生特异性反应。
抗共济失调毛细血管扩张突变（ATM）负责响应双链断裂（DSB）激活和稳定p53。ATM直接在Ser15上磷酸化p53，并同时激活其他激酶，这些激酶在其他位点磷酸化同一分子。此外，双分钟2（Hdm2）的人类同源物在Ser395上被ATM磷酸化，这种磷酸化抑制了Hdm2介导的p53降解。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Physical form
0.01 M磷酸盐缓冲液（pH 7.4，含有15 mM叠氮化钠）中的溶液
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
Pereg Y, et al.
Proceedings of the National Academy of Sciences of the USA, 102(14), 5056-5061 (2005)
Jasmin Roohi et al.
Journal of human genetics, 62(5), 581-584 (2017-01-27)
Ataxia-telangiectasia (A-T) is an autosomal recessive chromosome breakage disorder caused by mutations in the ATM gene. Typically, it presents in early childhood with progressive cerebellar dysfunction along with immunodeficiency and oculocutaneous telangiectasia. An increased risk of malignancy is also associated
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
Maya R, et al.
Genes & Development, 15(9), 1067-1067 (2001)
Marta Viana-Pereira et al.
PloS one, 6(5), e20588-e20588 (2011-06-04)
High grade gliomas (HGG) are one of the leading causes of cancer-related deaths in children, and there is increasing evidence that pediatric HGG may harbor distinct molecular characteristics compared to adult tumors. We have sought to clarify the role of
Armin M Gamper et al.
Nucleic acids research, 41(22), 10334-10344 (2013-09-17)
The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant replicative structures and resected double strand breaks. While many hundred candidate ATR substrates have been identified, the essential role of ATR in the replicative stress response has impeded
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