A1976
Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Aβ 42
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
dot blot
immunoblotting
immunohistochemistry
immunoprecipitation (IP)
indirect ELISA
radioimmunoassay
immunoblotting
immunohistochemistry
immunoprecipitation (IP)
indirect ELISA
radioimmunoassay
Species reactivity:
rat, human, mouse
Citations:
3
Technique(s):
dot blot: 0.05-1 μg/mL
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200
Uniprot accession no.:
产品名称
Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 4 kDa
species reactivity
rat, human, mouse
packaging
antibody small pack of 25 μg
technique(s)
dot blot: 0.05-1 μg/mL
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
proteolytically cleaved (Ala42)
Quality Level
Gene Information
human ... APP(351)
mouse ... App(11820)
rat ... App(54226)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Rabbit anti-Aβ42 is suitable for use in immunoblot, immunohistochemistry, immunoprecipitation, RIA, ELISA and dot blot applications.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Proteolytic cleavage of the amyloid precursor protein (APP) produces the small fragment amyloid β peptide. Cleavage of APP occurs mostly at residue 40 but to a lesser extent residue 42. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients.
Rabbit anti-amyloid peptide β, cleavage site 42 (Aβ42) antibody binds to human, mouse and rat Aβ42.
Immunogen
synthetic peptide of approximately 10 amino acid residues at the C-terminus of Aβ42.
Physical form
Solution in phosphate buffer, pH 7.4, containing approximately 25 μg of antibody.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
Kathlyn J Gan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8088-8102 (2020-09-26)
Emerging evidence supports roles for secreted extracellular matrix proteins in boosting synaptogenesis, synaptic transmission, and synaptic plasticity. SPARCL1 (also known as Hevin), a secreted non-neuronal protein, was reported to increase synaptogenesis by simultaneously binding to presynaptic neurexin-1α and to postsynaptic
Pimozide Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species.
Ukjin Kim et al.
Frontiers in pharmacology, 10, 1517-1517 (2020-02-06)
The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and
Bao-Xi Qu et al.
Journal of the neurological sciences, 260(1-2), 204-213 (2007-06-19)
Abeta42 peptide aggregation and deposition is an important component of the neuropathology of Alzheimer's disease (AD). Gene-gun mediated gene vaccination targeting Abeta42 is a potential method to prevent and treat AD. APPswe/PS1DeltaE9 transgenic (Tg) mice were immunized with an Abeta42
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