生物来源
mouse
质量水平
偶联物
alkaline phosphatase conjugate
抗体形式
purified from hybridoma cell culture
抗体产品类型
secondary antibodies
克隆
MB-11, monoclonal
表单
buffered aqueous glycerol solution
种属反应性
human
技术
direct ELISA: 1:35,000
dot blot: 1:20,000 using 20 ng of human IgM/dot
dot blot: 1:30,000 using 20 ng of human IgM/dot (chemiluminescence)
同位素/亚型
IgG2b
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
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一般描述
Human IgMs are the initial immunoglobulin isotypes that appear in blood in response to the first exposure to external antigens. IgMs have been implicated in CNS myelin repair and increased secretory IgM levels have been linked to rhino-conjunctivitis . Monoclonal Anti-Human IgM (μ-chain specific)-Alkaline Phosphatase antibody is specific for human IgM. The product does not react with human IgG, IgA or light chains.
Monoclonal Anti-Human IgM (mouse IgG2b isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
免疫原
Human IgM isolated from pooled normal human serum
应用
Anti-Human IgM (μ-chain specific)-Alkaline Phosphatase antibody purified from hybridoma cell culture has been used in immunocytochemistry and enzyme linked immunosorbent assay (ELISA)
外形
Solution in 0.05 M Tris buffer, pH 8.0, containing 1 mM MgCl2, 1% bovine serum albumin, 50% glycerol and 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis
Xu X, et al.
Disease models & mechanisms, 8(8), 831-842 (2015)
Ines Pree et al.
Journal of immunology (Baltimore, Md. : 1950), 179(8), 5309-5316 (2007-10-04)
Previously, we have constructed recombinant derivatives of the major birch pollen allergen, Bet v 1, with a more than 100-fold reduced ability to induce IgE-mediated allergic reactions. These derivatives differed from each other because the two recombinant Bet v 1
Johan Bours et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 243(5), 456-463 (2005-06-03)
With various methods, secretory immunoglobulin M (sIgM) was assessed in tears of patients with rhino-conjunctivitis. Tears were analyzed by microimmunoelectrophoresis (MIE), size-exclusion high-pressure liquid chromatography (SE-HPLC), sodium dodecyl sulphate (SDS) electrophoresis and isoelectric focusing. Only very small traces of serum
Ana Luísa Tomás et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39(11), 2205-2209 (2020-06-20)
Interest in the detection of specific anti-Pneumocystis jirovecii antibodies has emerged as less-invasive alternative diagnostic approaches. Here is presented the performance of an ELISA based on a recombinant synthetic multi-epitope kexin 1 (Kex1) antigen of P. jirovecii, previously developed. Results
Sina Sarikhani et al.
Applied biochemistry and biotechnology, 162(5), 1249-1257 (2010-02-18)
As IgM is the first isotype of antibody which appears in blood after initial exposure to a foreign antigen in the pattern of primary response, detection, and quantification of this molecule in blood seems invaluable. To approach these goals, generation
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