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Merck
CN

A2900

[Val5]-血管紧张素II 乙酸盐 水合物

≥95% (HPLC), angiotensin II type 1 receptor agonist, powder

别名:

血管紧张素II乙酸盐

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关于此项目

经验公式（希尔记法）:
C49H69N13O12 · xC2H4O2 · yH2O
分子量:
1032.15 (anhydrous free base basis)
UNSPSC Code:
12352209
PubChem Substance ID:
329770803
NACRES:
NA.77

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产品名称

[Val5]-血管紧张素II 乙酸盐 水合物, ≥95% (HPLC), powder

SMILES string

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

InChI key

INQPQDZJLFYCRH-AXOAQIBVSA-N

assay

≥95% (HPLC)

form

powder

composition

acetate, 1.2-10.4%

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

相关类别

General description

[Val5]-血管紧张素II（[Val5]-ANG Ii）是一种含ANG II模拟物，在ANG II八肽中含有缬氨酸作为第5个氨基酸取代异亮氨酸。

Application

[Val5]-血管紧张素II醋酸盐水合物已用于诱导：
  • 小鼠肾脏损伤，以研究人肝型脂肪酸结合蛋白（hL-FABP）的作用
  • 小鼠血管炎症，以研究胞质铜伴侣抗氧化剂-1（Atox1）与肿瘤坏死因子（TNF）受体相关因子4（TRAF4）之间的相互作用
  • 小鼠腹主动脉瘤（AAA），以研究血管ATP酶铜转运α（ATP7α）的作用

Biochem/physiol Actions

[Val5]-血管紧张素II可用作血管紧张素II 1型受体（AT1受体）的激动剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000481317
0000481317
0000443459
0000443459
0000441480

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Archita Das et al.
American journal of physiology. Cell physiology, 317(6), C1161-C1171 (2019-09-26)
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cytokine TNF-α-stimulated endothelial cells (ECs), cytosolic Cu chaperone antioxidant-1 (Atox1) functions as a Cu-dependent transcription
Yuhan Chen et al.
Cardiovascular research, 117(4), 1217-1228 (2020-07-02)
Elevated serum immunoglobulins have been associated with experimental and human hypertension for decades but whether immunoglobulins and B cells play a causal role in hypertension pathology is unclear. In this study, we sought to determine the role of B cells
D G Butler et al.
Archives internationales de pharmacodynamie et de therapie, 329(2), 272-282 (1995-03-01)
Pressor responses to [Ile5]-Angiotensin II and [Val5]-Angiotensin II were measured following single intravenous doses of 0.0075, 0.075, 0.375, 0.75 and 7.5 micrograms/kg b.w. in anesthetised rats. [Val5]-Angiotensin II was significantly (10 per cent) more potent than [Ile5]-angiotensin II when log
Daisuke Ichikawa et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 973-980 (2012-08-29)
To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang II and WT-Ang II) for 28 days.
H Fujioka et al.
The Tohoku journal of experimental medicine, 177(3), 183-192 (1995-11-01)
We investigated the degradation of angiotensin II by vascular endothelial cells and smooth muscle cells in vitro. When angiotensin II was incubated with confluent culture of endothelial cells or with serum free conditioned medium of the endothelial cells, angiotensin II
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