产品名称
抗-肌球蛋白（骨骼肌快肌）−碱性磷酸酶 小鼠抗, clone MY-32, purified from hybridoma cell culture
biological source
mouse
conjugate
alkaline phosphatase conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MY-32, monoclonal
form
buffered aqueous glycerol solution
species reactivity
rat, chicken, rabbit, mouse, human, bovine, guinea pig, feline
technique(s)
direct immunofluorescence: 1:150 using formalin-fixed, paraffin-embedded human or animal skeletal muscle sections
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYH1(4619), MYH2(4620)
mouse ... Myh1(17879), Myh2(17882)
rat ... Myh1(287408), Myh2(691644)
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Application
使用单克隆小鼠抗肌球蛋白（骨骼/快速）作为一抗，以1：90000的稀释度，通过蛋白质印迹对来自具有过去损伤的运动员的血清样品中的肌球蛋白（快）水平进行测定。
抗-肌球蛋白（骨骼肌快肌）碱性磷酸酶抗体（小鼠，单克隆）已用于骨骼肌快肌和新生儿肌球蛋白的免疫组化法检测和定位。在体内体外肌肉发育和横纹肌肉瘤诊断研究中，可用于肌纤维分型。
Biochem/physiol Actions
肌球蛋白属于马达蛋白，作用于肌动蛋白丝调节细胞移动。肌球蛋白也调节细胞形状和信号传导。骨骼肌肌球蛋白有三种′快′肌球蛋白重链亚型（IIa、IIx和IIb），一种′慢′β-肌球蛋白重链亚型，以及三种主要的肌球蛋白轻链(MLC)亚型。这些肌球蛋白亚型可调节骨骼肌缩短。
肌球蛋白（骨骼肌快肌）不仅可用于纤维分型，还可用于检测肌源性肿瘤。使用福尔马林固定石蜡包埋材料，可用于回顾性和前瞻性肌丝分型。
肌球蛋白（骨骼肌快肌）单克隆抗体特异性结合成体大鼠骨骼肌球蛋白重链IIa、IIb和IId(IIx)（快缩肌纤维）中的表位。该抗体产品对人、牛、猫、兔、小鼠、豚鼠和鸡同样也有反应性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
定位于肌球蛋白重链上的表位。可对骨骼肌中发现的快速（II型）和新生儿肌动蛋白分子进行染色，但不会对培养细胞中的心肌、平滑肌或非肌肉肌球蛋白染色。能与人类横纹肌肉瘤发生反应。
抗-肌球蛋白（骨骼肌快肌）单克隆抗体（小鼠IgG1亚型）来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。
Immunogen
兔肌肉肌球蛋白。
Physical form
0.05 M Tris（pH 8.0）溶液，含1%牛血清白蛋白、1 mM MgCl2、50%甘油和15 mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 2
法规信息
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