A4393
R-(−)-阿朴吗啡 盐酸盐 半水合物
calcined, ≥98% (with NaOH, titration)
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关于此项目
线性分子式:
C17H17NO2 · HCl · 1/2H2O
化学文摘社编号:
分子量:
312.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
206-243-0
MDL number:
Assay:
≥98% (with NaOH, titration)
Form:
calcined, (Powder to Crystalline Powder)
Storage condition:
protect from light, under inert gas
Quality Segment
assay
≥98% (with NaOH, titration)
form
calcined, (Powder to Crystalline Powder)
storage condition
protect from light, under inert gas
color
white to gray
mp
285-287 °C (lit.)
solubility
H2O: ~10 mg/mL, clear, yellow-green
SMILES string
Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68
InChI
1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
InChI key
CXWQXGNFZLHLHQ-DPFCLETOSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Application
R-(-)-阿朴吗啡盐酸半水化合物已用作多巴胺受体激动剂，研究对帕金森症大鼠旋转行为的影响。
Biochem/physiol Actions
R-(−)-阿朴吗啡是一种非选择性的D1和D2多巴胺受体激动剂。它对帕金森病和男性勃起功能障碍有治疗作用。R-(−)-阿朴吗啡还具有神经保护、自由基清除和催吐作用。阿朴吗啡可刺激大脑的化学感受器触发区。它会刺激大脑中的化学感受器触发区。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A4393-5G | 04061832088648 |
| A4393-100MG | 04061833374399 |
| A4393-250MG | 04061833374412 |
| A4393-1G | 04061833374405 |