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Merck
CN

A4393

R-(−)-阿朴吗啡 盐酸盐 半水合物

calcined, ≥98% (with NaOH, titration)

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关于此项目

线性分子式:
C17H17NO2 · HCl · 1/2H2O
化学文摘社编号:
41372-20-7
分子量:
312.79
NACRES:
NA.77
PubChem Substance ID:
24278821
UNSPSC Code:
12352210
EC Number:
206-243-0
MDL number:
MFCD00150904

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产品名称

R-(−)-阿朴吗啡 盐酸盐 半水合物, calcined, ≥98% (with NaOH, titration)

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1

InChI key

CXWQXGNFZLHLHQ-DPFCLETOSA-N

SMILES string

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

assay

≥98% (with NaOH, titration)

form

calcined
 (Powder to Crystalline Powder)

storage condition

protect from light
under inert gas

color

white to gray

mp

285-287 °C (lit.)

solubility

H2O: ~10 mg/mL, clear, yellow-green

Quality Level

200

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

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相关类别

Application

R-(-)-阿朴吗啡盐酸半水化合物已用作多巴胺受体激动剂，研究对帕金森症大鼠旋转行为的影响。

Biochem/physiol Actions

R-(−)-阿朴吗啡是一种非选择性的D1和D2多巴胺受体激动剂。它对帕金森病和男性勃起功能障碍有治疗作用。R-(−)-阿朴吗啡还具有神经保护、自由基清除和催吐作用。阿朴吗啡可刺激大脑的化学感受器触发区。它会刺激大脑中的化学感受器触发区。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000506642
0000506642
0000448048
0000448048
0000463583

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