A5111
ABT-724 trihydrochloride
≥98% (HPLC)
别名:
2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C17H19N5 · 3HCl
化学文摘社编号:
分子量:
402.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
ABT-724 trihydrochloride, ≥98% (HPLC)
InChI
1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H
SMILES string
Cl.Cl.Cl.C1CN(CCN1Cc2nc3ccccc3[nH]2)c4ccccn4
InChI key
AZFUVPBLKQGSRI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >30 mg/mL
originator
Abbott
storage temp.
2-8°C
Quality Level
Application
ABT-724 is a dopamine D4 receptor agonist. ABT-724 has been used in the study of impulsive behavior and penile erection in rats.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Mikhail N Koffarnus et al.
Behavioural pharmacology, 22(4), 300-311 (2011-06-23)
Impulsivity is widely regarded as a multidimensional trait that encompasses two or more distinct patterns of behavior, and dopaminergic systems are implicated in the expression of impulsive behavior in both humans and animal subjects. Impulsive choice, or the tendency to
Danuta Marona-Lewicka et al.
Psychopharmacology, 203(2), 265-277 (2008-07-08)
Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. The present study sought to characterize the effects of several dopamine D(4) agonists
Ronan Depoortère et al.
Behavioural pharmacology, 20(4), 303-311 (2009-07-09)
Dopamine (DA) is implicated in penile erection (PE) and yawning (YA) in rats through activation of D2-like receptors. However, the exact role of each subtype (D2, D3 and D4) of this receptor family in PE/YA is still not clearly elucidated.
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