A6608
白蛋白 人
recombinant, expressed in Saccharomyces cerevisiae, aqueous solution, 10% in aqueous buffer, ≥99% (agarose gel electrophoresis)
别名:
rHSA
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关于此项目
经验公式（希尔记法）:
C2936H4624N786O889S41
化学文摘社编号:
分子量:
66471.53
MDL编号:
UNSPSC代码:
12352202
eCl@ss:
42010201
NACRES:
NA.25
生物来源
human
质量水平
重组
expressed in Saccharomyces cerevisiae
方案
≥99% (agarose gel electrophoresis)
表单
aqueous solution
分子量
monomer ~67 kDa
浓度
10% in aqueous buffer
技术
cell culture | mammalian: suitable
UniProt登记号
储存温度
2-8°C
SMILES字符串
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
基因信息
human ... ALB(213)
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一般描述
Albumin constitutes 25% of the proteins produced by the liver and is a prominent protein found in the blood. It is a protein of a single polypeptide chain with a thiol group.
应用
该重组变异建议用于：吸收、分散、代谢和排泄（ADME）药理学研究；细胞培养；药物递送研究；细胞冻存。
Albumin human has been used:
- to study its adsorption process on model mica surface at pH 3.5 using the atomic force microscopy (AFM) and in situ streaming potential measurements
- to study its proteolytic activities under reducing conditions
- in the medium for stem cell cultivation
生化/生理作用
白蛋白是可见于动物体液和组织及部分植物种子的一类可溶性单体蛋白。 血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白。 血清白蛋白在调节血液的胶体渗透压方面也至关重要。
Albumin is a binding and transport protein that serves as a protein repository and a carrier for amino acids. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This also prevents the loss of substance through excretion. Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia. This product can be used in the pharmaceutical industry as a drug excipient and to coat medical devices.
分析说明
经过内毒素检测
其他说明
更多信息参见人血清白蛋白。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Dmitry Kryndushkin et al.
Pharmaceutical research, 33(2), 526-539 (2015-10-27)
Ascorbic acid has been considered as a potential radical scavenging excipient for pharmaceutical formulations. However, under certain circumstances, ascorbic acid can generate reactive oxygen species via redox cycling. The objective of this study was to investigate ascorbic acid-induced oxidative carbonylation
Dmitry Kryndushkin et al.
Pharmaceutical research, 34(4), 765-779 (2017-02-06)
Protein carbonylation is an irreversible modification of Lys, Arg, Thr and Pro amino acids under conditions of oxidative stress. Previous studies have reported specific carbonylated residues in purified recombinant albumins, albeit with a lack of agreement between the studies. Currently
Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls.
Jensen, et al.
International Journal of Molecular Sciences, 24 (2023)
Marta Kujda et al.
Colloids and surfaces. B, Biointerfaces, 127, 192-199 (2015-02-14)
Recombinant human serum albumin (rHSA) in monomeric state is widely used in pharmaceutical industry as a drug excipient and for preparing coatings for medical devices. In this work the adsorption process of rHSA on model mica surface at pH 3.5
Abnormalities of plasma proteins
Scientific Foundations of Biochemistry in Clinical Practice, 464-494 (1994)
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