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Merck
CN

A6981

阿坎酸钙

≥98% (HPLC), powder

别名:

3-（乙酰氨基）-1-丙磺酸钙盐 (2:1)

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关于此项目

经验公式（希尔记法）:
C5H10Ca0.5NO4S
化学文摘社编号:
77337-73-6
分子量:
200.24
MDL number:
MFCD00886588
UNSPSC Code:
12352200
PubChem Substance ID:
329770909
EC Number:
278-665-3
NACRES:
NA.77

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产品名称

阿坎酸钙, ≥98% (HPLC), powder

InChI

1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2

InChI key

BUVGWDNTAWHSKI-UHFFFAOYSA-L

SMILES string

CC(=O)NCCCS(=O)(=O)O[Ca]OS(=O)(=O)CCCNC(C)=O

assay

≥98% (HPLC)

form

powder

solubility

H2O: >5 mg/mL

storage temp.

room temp

Quality Level

100

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

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相关类别

Biochem/physiol Actions

阿坎酸钙是一种 GABAγ-氨基丁酸激动剂。
阿坎酸钙是一种γ-氨基丁酸（GABA）的合成类似物，同时也是一种GABAB受体激动剂。阿坎酸钙已被用于酒精依赖的治疗，可能是焦虑患者的一种有效的增效治疗。

Features and Benefits

《受体分类和信号转导》手册的 GABAA受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000421018
0000421018
0000362261
0000362261
052M4709V

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Fan Xu et al.
Arzneimittel-Forschung, 59(12), 631-634 (2010-01-30)
To study the pharmacokinetics of acamprosate calcium (CAS 77337-73-6) in healthy Chinese subjects after oral administration of three dosage levels, 12 healthy subjects were divided into three groups and given a single oral dose of 333 or 666 or 1332
Thomas L Schwartz et al.
The Annals of pharmacotherapy, 44(12), 1930-1932 (2010-11-11)
Glutamate is a major excitatory neurotransmitter, while γ-aminobutyric acid (GABA) is a predominant inhibitory neurotransmitter in the central nervous system. This GABA-glutamate imbalance is thought to play a role in the development of anxiety. Acamprosate calcium is thought to restore
Open-label trial of acamprosate as a treatment for anxiety.
Marc Hertzman et al.
Primary care companion to the Journal of clinical psychiatry, 11(5), 267-267 (2009-12-04)
M I Wilde et al.
Drugs, 53(6), 1038-1053 (1997-06-01)
Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduction
Alcohol dependence treatments: comprehensive healthcare costs, utilization outcomes, and pharmacotherapy persistence
Baser, O., et al.
The American Journal of Managed Care, 8, S222-S234 (2011)
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