产品名称
抗-水通道蛋白2 兔抗, IgG fraction of antiserum, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable
western blot: 1:200-1:1000 using using Rat Kidney membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AQP2(359)
mouse ... Aqp2(11827)
rat ... Aqp2(25386)
Application
使用浓度为5μg/ml的兔抗AQP2对10％福尔马林固定、石蜡包埋的大鼠肾脏切片进行免疫组织化学检测。使用抗AQP2可以观察到髓质粗大的升肢和集合管。
抗-水通道蛋白2兔抗可用于：
- 免疫染色
- 免疫组织化学
- 免疫荧光
- 免疫印迹
抗水通道水孔蛋白2抗体也适用于化学发光蛋白印迹（1：200-1：1000）和免疫印迹。
Biochem/physiol Actions
水通道蛋白（AQP2）N末端区域在运输中起着关键作用。C端磷酸化对根尖膜的透水功能至关重要。此外，在第270位赖氨酸的泛素化对于AQP2实现在溶酶体中的分类和降解，或通过外泌体实现消除是必需的。AQP2基因突变与先天性肾源性尿崩症（NDI）这种水平衡紊乱有关。AQP2的功能失调与先兆子痫、充血性心力衰竭以及肝硬化有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
水通道蛋白2（AQP2）以四聚体的形式存在，其C末端可具有多种构象并结合了两个镉离子。AQP2基因定位于人染色体12q13.12。它与细胞内囊泡有关。
水通道蛋白2（AQP2）是一种用于调节肾连合小管和集尿管中水平衡的水通道蛋白。AQP2由抗利尿激素激活，然后促进水分流入肾细胞。该蛋白还与整合素相互作用，以调节上皮细胞形态和细胞运动。抗水通道蛋白2抗体通过免疫印迹法识别大鼠中的水通道蛋白2。该抗体也与小鼠和人的AQP2发生反应。
Immunogen
对应于大鼠或小鼠水孔蛋白2（具有额外的N端赖氨酸和酪氨酸）的氨基酸254-271的合成肽通过戊二醛与KLH偶联。该表位在大鼠和小鼠中相同，在人类中高度保守。
Physical form
从含有磷酸盐缓冲液（pH 7.4）、1％BSA和0.05％叠氮化钠的溶液中冻干。
Preparation Note
分离于固定化蛋白A
未找到合适的产品？
试试我们的产品选型工具.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
常规特殊物品
此项目有
George J Schwartz et al.
The Journal of clinical investigation, 125(12), 4365-4374 (2015-11-01)
The nephron cortical collecting duct (CCD) is composed of principal cells, which mediate Na, K, and water transport, and intercalated cells (ICs), which are specialized for acid-base transport. There are two canonical IC forms: acid-secreting α-ICs and HCO3-secreting β-ICs. Chronic
Khalil El Karoui et al.
Nature communications, 7, 10330-10330 (2016-01-21)
In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions, which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid (PBA), a chemical chaperone already used in humans, as a novel therapeutic strategy capable to counteract the
Novel AVPR2 variant in a male infant with nephrogenic diabetes insipidus who showed delayed head control
Hasegawa K, et al.
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 28(4), 155-158 (2019)
Kuniaki Takata et al.
Histochemistry and cell biology, 130(2), 197-209 (2008-06-21)
Aquaporins (AQPs) are membrane proteins serving in the transfer of water and small solutes across cellular membranes. AQPs play a variety of roles in the body such as urine formation, prevention from dehydration in covering epithelia, water handling in the
Alexandra Rieger et al.
PloS one, 11(7), e0158977-e0158977 (2016-07-16)
During nephrogenesis, POU domain class 3 transcription factor 3 (POU3F3 aka BRN1) is critically involved in development of distinct nephron segments, including the thick ascending limb of the loop of Henle (TAL). Deficiency of POU3F3 in knock-out mice leads to
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持