A8843
AM580
≥98% (HPLC), RAR-α agonist, solid
别名:
4- [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）甲酰胺基] 苯甲酸
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关于此项目
经验公式（希尔记法）:
C22H25NO3
化学文摘社编号:
分子量:
351.44
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
AM580, ≥98% (HPLC)
SMILES string
CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O
InChI key
SZWKGOZKRMMLAJ-UHFFFAOYSA-N
InChI
1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
assay
≥98% (HPLC)
form
solid
storage temp.
−20°C
Quality Level
Gene Information
human ... RARA(5914), RARB(5915)
Application
类视黄醇衍生物用于白血病-视黄酸受体 (PHL-RAR) 细胞系分化的基因表达研究。
General description
AM580是视黄苯甲酸衍生物和RAR-α（视黄酸受体-α）激动剂。它刺激 NB4 早幼粒细胞白血病细胞系和 APL（急性早幼粒细胞白血病）原始细胞中粒细胞的成熟。AM580 抑制子宫内膜癌细胞增殖。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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