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Merck
CN

B5399

Sigma-Aldrich

(±)-巴氯芬

≥98% (HPLC), solid

别名:

(±)-β-(氨甲基)-4-氯苯丙酸, 巴氯芬片

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About This Item

经验公式(希尔记法):
C10H12ClNO2
CAS号:
分子量:
213.66
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32

质量水平

方案

≥98% (HPLC)

表单

solid

颜色

white to very faintly yellow

溶解性

1 M HCl: 50 mg/mL

储存温度

2-8°C

SMILES字符串

ClC1=CC=C(C(CN)CC(O)=O)C=C1

InChI

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

InChI key

KPYSYYIEGFHWSV-UHFFFAOYSA-N

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应用

(±)-巴氯芬作为γ-氨基丁酸B受体(GABAB受体)激动剂已用于:
  • 作为GABA能药物对照,检测其对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的多巴胺能毒性的保护作用
  • 检测其对突变小鼠体内运动能力测试和表现的影响
  • 检测其对腹侧被盖区多巴胺能(DA)神经元的兴奋作用
  • 检测其对浦肯野神经元树突兴奋性降低的作用

生化/生理作用

GABA B 受体激动剂;骨骼肌松弛剂;解痉剂。
巴氯芬(Baclofen),是一种γ-氨基丁酸(GABA)类似物,具有肌肉松弛作用。作为一种γ-氨基丁酸受体B(GABAB)激动剂,巴氯芬可增强树突钾K通道的活动。它可用于抑制胃食管反流病(GERD)的一过性食管下括约肌松弛(TLESR)。巴氯芬也可用于治疗成瘾症,尤其是酒精使用障碍(AUD)。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

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The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.
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