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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to very faintly yellow
溶解性
1 M HCl: 50 mg/mL
储存温度
2-8°C
SMILES字符串
ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key
KPYSYYIEGFHWSV-UHFFFAOYSA-N
基因信息
human ... GABBR1(2550) , GABBR2(9568)
rat ... Gabbr1(81657) , Gabra2(29706)
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应用
(±)-巴氯芬作为γ-氨基丁酸B受体(GABAB受体)激动剂已用于:
- 作为GABA能药物对照,检测其对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的多巴胺能毒性的保护作用
- 检测其对突变小鼠体内运动能力测试和表现的影响
- 检测其对腹侧被盖区多巴胺能(DA)神经元的兴奋作用
- 检测其对浦肯野神经元树突兴奋性降低的作用
生化/生理作用
GABA B 受体激动剂;骨骼肌松弛剂;解痉剂。
巴氯芬(Baclofen),是一种γ-氨基丁酸(GABA)类似物,具有肌肉松弛作用。作为一种γ-氨基丁酸受体B(GABAB)激动剂,巴氯芬可增强树突钾K+ 通道的活动。它可用于抑制胃食管反流病(GERD)的一过性食管下括约肌松弛(TLESR)。巴氯芬也可用于治疗成瘾症,尤其是酒精使用障碍(AUD)。
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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