B7148
丁螺环酮盐酸盐 盐酸盐
≥99% (TLC), powder, 5-HT1A serotonin receptor agonist
别名:
N-[4-[4-(2-嘧啶基)-1-哌嗪基] 丁基]-8-氮杂螺[4.5]癸烷-7,9-二酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C21H31N5O2 · HCl
化学文摘社编号:
分子量:
421.96
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-489-4
MDL number:
产品名称
丁螺环酮盐酸盐 盐酸盐,
InChI key
RICLFGYGYQXUFH-UHFFFAOYSA-N
InChI
1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
SMILES string
Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4
form
powder
originator
Bristol-Myers Squibb
storage temp.
2-8°C
Quality Level
Gene Information
human ... HTR1A(3350)
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相关类别
Biochem/physiol Actions
5-HT 1A 血清素受体激动剂；抗焦虑药。
Features and Benefits
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
G Tunnicliff
Pharmacology & toxicology, 69(3), 149-156 (1991-09-01)
Buspirone has been available in the United States for over four years for the treatment of anxiety. It was anticipated this drug would offer certain advantages over the established benzodiazepines. In contrast to diazepam, early studies found no evidence for
E Meller et al.
Molecular pharmacology, 37(2), 231-237 (1990-02-01)
The irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was used to determine the relationship between receptor occupancy and response at central 5-hydroxytryptamine1A (5-HT1A) serotonin receptors mediating the inhibition of serotonin synthesis in rat cortex and hippocampus. Rats were treated with vehicle or
Hedayat Nazari et al.
Archives of gynecology and obstetrics, 287(3), 469-472 (2012-10-18)
The premenstrual syndrome (PMS), which causes emotional and physical symptoms, is a common problem in many women in their reproductive age. Many approaches to PMS with controversial results are available. The present study was performed to compare fluoxetine and buspirone
D F Avgustinovich et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 98(6), 693-705 (2012-09-28)
The influence of acute and chronic (14 days) buspirone administration (1 mg/kg, intraperitoneally) on the behavior of C57BL/6J female mice, being in social discomfort, were studied. The conditions of social discomfort include the permanent habitation of females in the cage
Theresa Winhusen et al.
Contemporary clinical trials, 33(5), 993-1002 (2012-05-23)
Cocaine dependence is a significant public health problem for which there are currently no FDA-approved medications. Hence, identifying candidate compounds and employing an efficient evaluation process is crucial. This paper describes key design decisions made for a National Institute on
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