C0493
Monoclonal Anti-Calcium Sensing Receptor 小鼠抗
clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture
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关于此项目
Conjugate:
unconjugated
Clone:
HL1499 (6D4-3F4-6C4), monoclonal
Application:
ELISA (i), ICC, IHC (p), WB
Citations:
10
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HL1499 (6D4-3F4-6C4), monoclonal
form
buffered aqueous solution
species reactivity
rabbit, rat, mouse, human
technique(s)
immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 3-6 μg/mL using total extract from rat kidney
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CASR(846)
mouse ... Casr(12374)
rat ... Casr(24247)
General description
The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.
Immunogen
peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.
Application
Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:
- Indirect ELISA
- Immunoblotting
- Immunocytochemistry
- Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
- Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney
Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.
Taguchi K, et al.
European eurology focus, 3, Taguchi K-Taguchi K (2017)
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells
Vaz CV, et al.
Biochimica et Biophysica Acta, 1853, 2621-2628 (2015)
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease.
Emanuela G, et al.
Frontiers in Neuroscience, 2017 -2017 null
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.
Catia V V, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1853(10), 2621-2628 (2015)
Calcium-Sensing Receptors
Goodman WG, et al.
Seminars in Nephrology, 24, 17-24 (2004)
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