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Merck
CN

C130

氯-APB 氢溴酸盐

solid

别名:

(±)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓 氢溴酸盐, (±)-SKF-82958 氢溴酸盐, 6-氯-N-烯丙基-SKF-38393 氢溴酸盐

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关于此项目

经验公式(希尔记法):
C19H20ClNO2 · HBr
化学文摘社编号:
分子量:
410.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

SMILES string

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI key

WLXGFAVTAAQOFH-UHFFFAOYSA-N

form

solid

color

tan

solubility

H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble

storage temp.

2-8°C

Quality Level

Gene Information

human ... DRD1(1812)

Application

氯-APB氢溴酸盐用于药理学刺激D1多巴胺受体,研究其对小鼠脂肪量和肥胖相关蛋白(FTO)缺陷多巴胺D1受体表达的中刺状神经元(D1 MSN)运动反应的影响。

Biochem/physiol Actions

氯-APB氢溴酸盐又名SKF 82958,是一种D1多巴胺受体激动剂。D1受体激动剂预防和逆转芬太尼诱导的呼吸抑制,而不损害猫的阿片类镇痛作用。

Disclaimer

光敏性

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Liad Mann et al.
The international journal of neuropsychopharmacology, 11(4), 533-539 (2008-01-22)
Lithium ions' inhibition of adenylyl cyclase (AC) has not been previously studied for the newly discovered AC isoforms. COS7 cells were transfected with each of the nine membrane-bound AC isoforms cDNAs with or without D1- or D2-dopamine receptor cDNA. AC
Neil E Paterson et al.
European journal of pharmacology, 616(1-3), 73-80 (2009-06-06)
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor activity was dependent on harmaline dose. The first-line clinical essential tremor treatments propranolol, primidone and
Peter M Lalley
American journal of physiology. Regulatory, integrative and comparative physiology, 289(1), R45-R51 (2005-02-12)
Opioids depress respiration and decrease chest wall compliance. A previous study in this laboratory showed that dopamine-D(1) receptor (D(1)R) agonists restored phrenic nerve activity after arrest by fentanyl in immobilized, mechanically ventilated cats. The reinstated phrenic nerve rhythm was slower
Stefanie Dedeurwaerdere et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 210-217 (2011-07-12)
Phosphodiesterase 10A (PDE10A) inhibitors have recently been proposed as a new therapy for schizophrenia. The aim of this study was to enhance our understanding of the role of PDE10A inhibitors and potentially identify a clinically useful mechanistic/functional biomarker by using
Elena H Chartoff et al.
Psychopharmacology, 204(2), 227-239 (2009-01-17)
Chronic opiate administration induces neuroadaptations within the nucleus accumbens (NAc) and ventral tegmental area (VTA) that can contribute to dependence. We have shown that morphine dependence shifts the behavioral consequences of D1 dopamine (DA) receptor signaling: systemic administration of a

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