C130
氯-APB 氢溴酸盐
solid
别名:
(±)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓 氢溴酸盐, (±)-SKF-82958 氢溴酸盐, 6-氯-N-烯丙基-SKF-38393 氢溴酸盐
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关于此项目
经验公式（希尔记法）:
C19H20ClNO2 · HBr
化学文摘社编号:
分子量:
410.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
产品名称
氯-APB 氢溴酸盐, solid
InChI
1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
SMILES string
Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
InChI key
WLXGFAVTAAQOFH-UHFFFAOYSA-N
form
solid
color
tan
solubility
H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... DRD1(1812)
相关类别
Application
氯-APB氢溴酸盐用于药理学刺激D1多巴胺受体，研究其对小鼠脂肪量和肥胖相关蛋白(FTO)缺陷多巴胺D1受体表达的中刺状神经元(D1 MSN)运动反应的影响。
Biochem/physiol Actions
氯-APB氢溴酸盐又名SKF 82958，是一种D1多巴胺受体激动剂。D1受体激动剂预防和逆转芬太尼诱导的呼吸抑制，而不损害猫的阿片类镇痛作用。
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
K D Carr et al.
Neuroscience, 165(4), 1074-1086 (2009-11-26)
Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in
Jennifer L Cornish et al.
Journal of psychopharmacology (Oxford, England), 22(1), 100-110 (2008-01-12)
Methamphetamine is a drug that is often consumed at dance parties or nightclubs where the ambient temperature is high. The present study determined whether such high ambient temperatures alter intravenous methamphetamine self-administration in the rat. Male Hooded Wistar rats were
Thomas F Tropea et al.
Biological psychiatry, 63(11), 1066-1074 (2008-02-16)
Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after prenatal exposure to cocaine. The present study
Liad Mann et al.
Bipolar disorders, 11(8), 885-896 (2009-11-20)
Lithium, valproate, and carbamazepine decrease stimulated brain cyclic-AMP (cAMP) levels. Adenylyl cyclase (AC), of which there are nine membrane-bound isoforms (AC1-AC9), catalyzes the formation of cAMP. We have recently demonstrated preferential inhibition of AC5 by lithium. We now sought to
A M Murray et al.
European journal of pharmacology, 160(3), 377-384 (1989-02-07)
A range of 3- and 6-substituted 1-phenyl-1H-3-benzazepine analogues of SK&F 38393 with D-1 agonist activity were compared for their behavioural effects in the intact adult rat and for their relative affinities for D-1 and D-2 dopamine receptors in vitro. All
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