C1603
抗 钙通道（α 1C 亚基）（L-型电压门控 Ca2+ 通道） 兔抗
affinity isolated antibody
别名:
Anti-CACH2, Anti-CACN2, Anti-CACNL1A1, Anti-CCHL1A1, Anti-CaV1.2, Anti-LQT8, Anti-TS, Anti-TS. LQT8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat, mouse, rabbit
technique(s)
immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Cacna1c(12288)
General description
电压门控钙通道 L 型 (L—型 VGCC) 是一种高电压激活的通道，对细胞钙离子浓度发挥时空控制作用，调节神经递质释放、激素分泌、肌肉收缩、电活动、细胞代谢和增殖、基因表达和神经元存活等功能。钙依赖性过程在突触修饰中很重要，因此钙通道功能的改变可能对突触可塑性和年龄相关的神经退行性疾病都很重要。钙通道拮抗剂用作抗心律失常药和治疗高血压，甚至在帕金森病中可能具有神经保护作用。钙离子通道 α1C 亚基是一种成孔亚基，与 βC 类 L 型钙通道的膜靶向所必需的信号。
Immunogen
对应于大鼠 α848-865 位氨基酸的合成肽1C.
Application
兔多克隆抗钙通道 α用抗体标记 C 类 L 型钙通道亚基 α1C 通过免疫细胞化学和免疫组织化学 (IHC) 技术（如 ELISA、免疫印迹和免疫沉淀）进行检测和定量。用作探针以确定钙通道亚单位 α 的存在和作用C 类 L 型电压门控 Ca 2 + 通道亚基复合物中的 1C。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫组织化学（1篇论文）
免疫组织化学（1篇论文）
抗钙通道（α1C 亚基）（L 型电压门控Ca2+通道）兔源抗体可用于：
- SDS-PAGE
- 蛋白质印迹
- 免疫共沉淀
Biochem/physiol Actions
抗电压门控钙通道 α1C 亚基识别 α用免疫印迹法在大鼠脑和大鼠心脏膜中检测 1C 亚基。已证实大鼠、小鼠、兔和人的反应性。
Physical form
从含有 1% 牛血清白蛋白和 0.05% 叠氮化钠的磷酸盐缓冲盐水 (pH 7.4) 冻干。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
含少量动物源组分生物产品
此项目有
Calcium channel function and regulation in beta1-and beta2-adrenoceptor transgenic mice
Foerster K, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 369(5), 490-495 (2004)
Jing Liu et al.
American journal of physiology. Cell physiology, 297(1), C152-C159 (2009-04-10)
Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported that Ca(2+) handling, crucial to excitation-contraction coupling of hESC-derived CMs (hESC-CMs), is functional but immature. Such immature properties as
Nina Daschil et al.
Pharmacology, 93(1-2), 24-31 (2014-01-18)
It is well established that reactive astrocytes express L-type calcium channels (LTCC), but their functional role is completely unknown. We have recently shown that reactive astrocytes highly express the CaV1.2 α1-subunit around β-amyloid (Aβ) plaques in an Alzheimer mouse model.
A S Axelsson et al.
Nature communications, 8, 15652-15652 (2017-06-07)
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective
Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells
Kato HK, et al.
The Journal of Physiology, 590(13), 3019-3034 (2012)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持