产品名称
Corticosterone: HBC complex, free flowing powder
SMILES string
O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
biological source
synthetic (organic)
sterility
non-sterile
assay
≥91.5% (HPLC)
form
free flowing powder
shipped in
ambient
storage temp.
room temp
Quality Level
Application
Corticosterone: HBC complex has been used:
- in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
- to induce acute stress in mice
- in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Biochem/physiol Actions
The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.
Preparation Note
Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.
Other Notes
Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
B L Conway-Campbell et al.
Journal of neuroendocrinology, 22(10), 1093-1100 (2010-07-24)
In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient amplitude to activate the low affinity glucocorticoid receptor (GR). Discrete pulses readily access brain
Angela M Ives et al.
Journal of virology, 91(13) (2017-04-14)
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with the exacerbation of clinical symptoms
CORT, Cort, B, Corticosterone, and now Cortistatin: Enough Already!
Hershel Raff
Endocrinology, 157(9), 3307-3308 (2016-07-29)
Marlena Wosiski-Kuhn et al.
Psychoneuroendocrinology, 42, 165-177 (2014-03-19)
Diabetes and obesity are associated with perturbation of adrenal steroid hormones and impairment of hippocampal plasticity, but the question of whether these conditions recruit glucocorticoid-mediated molecular cascades that are comparable to other stressors has yet to be fully addressed. We
Jan Kroon et al.
Molecular metabolism, 47, 101179-101179 (2021-02-07)
Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) uptake by BAT, we investigated
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持