C2899
金雀花碱
≥99%, powder
别名:
(-)-金雀花碱, (1S,9S)-3,11-二氮杂三环[7.3.1.03,8]三癸-5,7-二烯-4-酮, 野靛碱
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关于此项目
经验公式（希尔记法）:
C11H14N2O
化学文摘社编号:
分子量:
190.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
207-616-0
MDL number:
Quality Level
assay
≥99%
form
powder
color
light yellow
bp
218 °C/2 mmHg (lit.)
mp
154-156 °C (lit.)
SMILES string
O=C1C=CC=C2C3CNCC(C3)CN12
InChI
1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
InChI key
ANJTVLIZGCUXLD-DTWKUNHWSA-N
Gene Information
rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590)
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General description
Cytisine is an alkaloid present in Cytisus laburnum, particularly in its seeds. It might be effective for smoking cessation. Cytisine is a natural insecticide. It has a molecular structure similar to nicotine. Cytisine may have antidepressant like properties.
Biochem/physiol Actions
α3β4 和 α7 烟碱型乙酰胆碱受体的强效激动剂，α4β2 烟碱型乙酰胆碱受体的部分激动剂。
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Natalie Walker et al.
BMC public health, 11, 880-880 (2011-11-23)
Smokers need effective support to maximise the chances of successful quit attempts. Current smoking cessation medications, such as nicotine replacement therapy (NRT), bupropion, nortriptyline or varenicline, have been shown to be effective in clinical trials but are underused by smokers
Edwin G Pérez et al.
Natural product reports, 29(5), 555-567 (2012-03-01)
Covering: up to the end of 2011. This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions with
Michael J Marks et al.
Journal of neurochemistry, 130(2), 185-198 (2014-03-26)
Nicotinic acetylcholine receptors (nAChR) of the α6β2* subtype (where *indicates the possible presence of additional subunits) are prominently expressed on dopaminergic neurons. Because of this, their role in tobacco use and nicotine dependence has received much attention. Previous studies have
Peter Hajek et al.
Thorax, 68(11), 1037-1042 (2013-02-14)
A recent rigorous study has shown that cytisine, a low-cost drug, is effective for smoking cessation. A number of earlier studies exist, mostly from former communist countries where cytisine has been used since the 1960s. The key question now is
Henrik Viberg et al.
Toxicology, 289(1), 59-65 (2011-08-09)
Flame retardants such as polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A are used as flame retardants and detected in the environmental, wildlife species and human tissues. Exposure to PBDEs during the neonatal development of the brain has been shown to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C2899-25MG | 04061832941028 |
| C2899-100MG | 04061832941011 |
| C2899-250MG | 04061832283678 |
| C2899-5MG | 04061833484814 |
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