产品名称
抗钙粘附蛋白抗体，小鼠单克隆抗体 小鼠抗, clone GC-4, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
GC-4, monoclonal
form
buffered aqueous solution
mol wt
antigen 135 kDa
species reactivity
chicken, monkey, mouse, human, rabbit, rat
technique(s)
electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
isotype
IgG1
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)
Physical form
在pH7.4的0.01M磷酸盐缓冲盐水中，用0.2μl过滤的溶液。
General description
N-钙粘着蛋白是钙粘着蛋白家族的成员，其以钙依赖性方式介导细胞粘着。N-钙粘着蛋白是一种跨膜糖蛋白，位于质膜的细胞粘着连接处。现已确知该蛋白质位于细胞膜中。
Other Notes
克隆 GC-4 也称为 GB-9。
Application
Anti-N-Cadherin 抗体适用于以下程序：
- 电子显微镜术
- 流式细胞术
- 免疫细胞化学
- 免疫组化，浓度为 10-20μ g/mL，使用大鼠心肌冷冻切片
- 免疫印迹，浓度为 10-20μg/mL，使用鸡心肌或 COS-7 细胞提取物
Biochem/physiol Actions
CDH11 基因编码一种介导钙依赖性细胞间黏附的 Ⅱ 类型经典钙粘蛋白。
在肿瘤细胞中观察到CDH2基因的更高表达。现已确知它诱导癌细胞的侵袭性和化学抗性。N-钙粘着蛋白的N-糖基化与肿瘤发生过程有关，特别是与乳腺、肾系统和卵巢中的肿瘤发生过程有关。在肾上腺皮质癌中观察到该基因没有表达。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
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