C3920
软骨素二糖 δdi-0S 钠盐
≥95% (HPLC)
别名:
α-ΔUA-[1→3]-GalNAc
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关于此项目
线性分子式:
C14H20NO11Na
化学文摘社编号:
分子量:
401.30
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
产品名称
软骨素二糖 δdi-0S 钠盐, ≥95% (HPLC)
InChI key
SDRQEYWJTBWGNE-UHFFFAOYSA-N
SMILES string
[Na].CC(=O)NC(C=O)C(OC1OC(=CC(O)C1O)C(O)=O)C(O)C(O)CO
InChI
1S/C14H21NO11.Na.H/c1-5(18)15-6(3-16)12(10(21)8(20)4-17)26-14-11(22)7(19)2-9(25-14)13(23)24;;/h2-3,6-8,10-12,14,17,19-22H,4H2,1H3,(H,15,18)(H,23,24);;
assay
≥95% (HPLC)
form
powder
color
white
solubility
H2O: soluble 10 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
软骨素二糖 δdi-0S 可用作鉴定和表征酶（如产气荚膜梭菌 不饱和葡糖醛酸水解酶 ）的底物。软骨素二糖 δ双-0S 可作为引用软骨素二糖分析中的参比化合物。
General description
软骨素是一种氨基葡萄糖聚糖 (GAG)，是 N-乙酰半乳糖胺 (GalNAc) 和葡萄糖醛酸 (GlcA) 交替单位组成的多糖链，可在 GalNAc 和/或GlcA 单位上发生硫酸化。软骨素及其硫酸盐经常附着在蛋白质上形成蛋白聚糖。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yusuke Nakamichi et al.
The Journal of biological chemistry, 286(8), 6262-6271 (2010-12-15)
Pathogenic Streptococcus agalactiae produces polysaccharide lyases and unsaturated glucuronyl hydrolase (UGL), which are prerequisite for complete degradation of mammalian extracellular matrices, including glycosaminoglycans such as chondroitin and hyaluronan. Unlike the Bacillus enzyme, streptococcal UGLs prefer sulfated glycosaminoglycans. Here, we show
Glucosamine and chondroitin sulfate.
Miller KL, Clegg DO.
Rheumatic Diseases Clinics of North America, 23(1), 103-118 (2011)
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.
Galtrey CM, Fawcett JW.
Brain Research. Brain Research Reviews, 54, 1-18 (2007)
Kemal Solakyildirim et al.
Analytical biochemistry, 397(1), 24-28 (2009-09-23)
Chondroitin sulfate (CS) has an important role in cell division, in the central nervous system, and in joint-related pathologies such as osteoarthritis. Due to the complex chemical structure and biological importance of CS, simple, sensitive, high resolution, and robust analytical
J C F Kwok et al.
The international journal of biochemistry & cell biology, 44(4), 582-586 (2012-01-24)
Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding
商品
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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