Name: Ciglitizone
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₈H₂₃NO₃S

CAS Number:

74772-77-3

分子量:

333.45

MDL编号:

MFCD00865499

UNSPSC代码:

12352200

PubChem化学物质编号:

24892661

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

创始人

Takeda

SMILES字符串

CC1(CCCCC1)COc2ccc(CC3SC(=O)NC3=O)cc2

InChI

1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)

InChI key

YZFWTZACSRHJQD-UHFFFAOYSA-N

基因信息

human ... PPARG(5468)
mouse ... Pparg(19016)

应用

Ciglitizone has been used as a proliferator-activated receptor γ (PPARγ) agonist:

to study its effects on cell proliferation in human melanocytes
to study its effects on pigmentation and migration of human melanocytes

It also may be used to study its effects on cell cycle and apoptosis in monocytic cells.

生化/生理作用

Ciglitizone belongs to the class of thiazolidinediones and is a peroxisome proliferator-activated receptor γ (PPARγ) agonist. It exhibits anti-diabetic activity. Ciglitizone has the potential to treat tumor necrosis factor α (TNFα)-related apoptosis-inducing ligand (TRAIL)-refractory high-grade urothelial cancers.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.