C7113
抗-降钙素基因相关肽小鼠单克隆抗体
clone 4901, purified from hybridoma cell culture
别名:
Anti-CALC, Anti-CCALCI, Anti-CGRP-I
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关于此项目
Conjugate:
unconjugated
Clone:
4901, monoclonal
Application:
ELISA (i), ICC, Neutral, RIA
Citations:
39
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
4901, monoclonal
form
buffered aqueous solution
species reactivity
rat, human, canine
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable, indirect ELISA: 0.5 μg/mL using rat α-CGRP, neutralization: suitable, radioimmunoassay: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CALCA(796)
rat ... Calca(24241)
General description
CGRP（降钙素基因相关肽）属于降钙素家族，主要在中枢和周围神经系统中表达。它是一种强效血管舒张剂。偏头痛发作时CGRP 浓度增加， 因此，它参与偏头痛的发病机理。单克隆抗-降钙素基因相关肽抗体可用于免疫中和和放射免疫测定。小鼠抗降钙素基因相关肽抗体与大鼠α-CGRP的C末端10个氨基酸中的抗原表位发生特异性反应，并且与人和狗的α和β-CGRP发生交叉反应。
降钙素基因相关肽（CGRP）是一种血管舒张剂，属于降钙素肽家族。它由周围和中枢神经紧张系统的运动神经元产生。CGRP有两种形式，α和β，它们具有相似的功能。CGRP的作用是由降钙素受体样受体（CRLR）和受体活性修饰蛋白1（RAMP1）形成的G蛋白偶联受体异二聚体介导的。 CGRP在神经紧张、内分泌、免疫和心血管系统中具有多种生物学作用。 多项研究表明CGRP与偏头痛的病理生理有关，研究人员正在探索将CGRP的拮抗剂作为治疗方案。
单克隆抗降钙素基因相关肽（CGRP）可识别大鼠α-CGRP。该抗体可与人和狗的α-和β-CGRP发生交叉反应。
单克隆抗降钙素基因相关肽（CGRP）可识别大鼠α-CGRP。该抗体可与人和狗的α-和β-CGRP发生交叉反应。
Immunogen
大鼠α-CGRP肽。抗体识别的表位位于大鼠α-CGRP的C端十个氨基酸内。
Application
单克隆抗降钙素基因相关肽抗体可用于免疫细胞化学和免疫组化。它也可以用于ELISA中。
抗降钙素基因相关肽（CGRP）抗体适用于ELISA ，工作浓度为0.25- 0.5 μg/ml。该抗体可以在大鼠神经纤维和人背根神经节中以1：100的工作稀释度用于免疫荧光。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Ian De Proost et al.
Histochemistry and cell biology, 128(4), 301-316 (2007-08-11)
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Steve J Sullivan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(25), 6007-6020 (2017-06-01)
In the brain, transmembrane AMPAR regulatory proteins (TARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these auxiliary subunits to AMPAR-mediated signaling in the spinal cord remains unclear. We found that the Type I TARP
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