C7464
抗-Cyclin D1单克隆抗体 小鼠抗
clone DCS-6, ascites fluid
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关于此项目
Conjugate:
unconjugated
Clone:
DCS-6, monoclonal
Application:
immunocytochemistry
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (frozen sections)
immunoprecipitation (IP)
microarray
western blot
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (frozen sections)
immunoprecipitation (IP)
microarray
western blot
Species reactivity:
rat, mouse, human, monkey
Citations:
25
Technique(s):
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:200 using a human tumor cell line extract
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:200 using a human tumor cell line extract
Uniprot accession no.:
产品名称
抗-Cyclin D1单克隆抗体 小鼠抗, clone DCS-6, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
DCS-6, monoclonal
mol wt
antigen 36 kDa (several lower and higher molecular weight bands)
contains
15 mM sodium azide
species reactivity
rat, mouse, human, monkey
technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:200 using a human tumor cell line extract
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CCND1(595)
mouse ... Ccnd1(12443)
rat ... Ccnd1(58919)
Application
小鼠抗周期蛋白 D1 单克隆抗体可用于：
- 免疫印迹
- 免疫荧光
- 免疫细胞化学
- 免疫沉淀
- 免疫组化
- 抗体介导的敲除实验
Biochem/physiol Actions
不与其他D型细胞周期蛋白交叉反应。
周期蛋白 D1 参与调控周期蛋白依赖性激酶（CDK）家族成员。周期蛋白 D1 和 D2 与CDK4 和/或 CDK6 激酶活性相关，可在G1 期中期观察到，在G1 期后期达到顶峰。在相当比例的癌症中观察到周期蛋白D1 基因扩增，这些癌症包括乳腺癌、膀胱癌、套细胞淋巴瘤、头颈部癌。在食道鳞状细胞癌中也发现这一基因扩增。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
抗周期蛋白D1 单克隆抗体（小鼠IgG2a同种型）来自DCS-6杂交瘤，该杂交瘤由小鼠骨髓瘤细胞和免疫小鼠的脾细胞融合产生。周期蛋白 D1 蛋白是哺乳动物细胞G1期周期蛋白。这一蛋白是D型周期蛋白。CCD1基因位于人染色体11q13.3。
Immunogen
重组人细胞周期蛋白D1蛋白。
Physical form
该产品以含有 15mM 叠氮化钠（作为保存剂）的腹水形式提供。
Preparation Note
如需连续使用，可在2-8 °C保存至多一月。对于更长期的存储，可对溶液进行等分并冷冻保存。不建议反复冻融。不建议储存在无霜冰箱中。如果长期储存时出现轻微浑浊，请在使用前通过离心澄清溶液。
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wgk
WGK 3
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Mu Yao et al.
The British journal of nutrition, 108(3), 424-430 (2011-11-10)
We have developed a blend of food extracts commonly consumed in the Mediterranean and East Asia, named blueberry punch (BBP), with the ultimate aim to formulate a chemoprevention strategy to inhibit prostate cancer progression in men on active surveillance protocol.
Takeshi Shimamura et al.
Cancer research, 65(14), 6401-6408 (2005-07-19)
Somatic mutations in the kinase domain of the epidermal growth factor receptor (EGFR), including L858R and exon 19 deletions, underlie responsiveness to gefitinib and erlotinib in non-small cell lung cancer (NSCLC). Acquired resistance to these tyrosine kinase inhibitors is in
S John Weroha et al.
Carcinogenesis, 27(3), 491-498 (2005-11-29)
A common feature of human breast oncogenesis is cell cycle deregulation. The expression of cyclins D1 and D3 was examined during estradiol-17beta (E(2))-induced mammary tumorigenesis in female August Copenhagen Irish (ACI) rats. Low serum E(2) levels ( approximately 60-120 pg/ml)
Christopher T Capaldo et al.
Molecular biology of the cell, 22(10), 1677-1685 (2011-03-18)
Coordinated regulation of cell proliferation is vital for epithelial tissue homeostasis, and uncontrolled proliferation is a hallmark of carcinogenesis. A growing body of evidence indicates that epithelial tight junctions (TJs) play a role in these processes, although the mechanisms involved
Yanhong Yang et al.
Oncology letters, 15(4), 5280-5284 (2018-03-20)
Nimotuzumab, a humanized IgG1 monoclonal antibody against epidermal growth factor receptor (EGFR), increases radiosensitivity in lung cancer. Cisplatin is an effective antitumor agent in lung cancer. In the present study, the antitumor activity of nimotuzumab combined with cisplatin was investigated
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