C8946
α-糜蛋白酶 来源于人类胰腺
lyophilized powder
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-671-2
MDL number:
Biological source:
human pancreas
biological source
human pancreas
form
lyophilized powder
mol wt
25 kDa
packaging
vial of ≥10 BTEE units
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... CTRB1(1504)
General description
α-胰凝乳蛋白酶属于丝氨酸蛋白酶的胰蛋白酶家族。它作为无活性的前体胰凝乳蛋白酶原分泌到肠中。第148位氨基酸的肽键断裂形成α-胰凝乳蛋白酶。胰凝乳蛋白酶原由基因CTRB1编码，并定位于人类染色体中的16q23.1。
Application
α-来自人胰腺的胰凝乳蛋白酶已用于检测N-烷基靛红对哺乳动物丝氨酸蛋白酶的抑制作用。
人α-胰凝乳蛋白酶已用于一项研究中，以评估有机磷酸酯与胰蛋白酶和胰凝乳蛋白酶结合的定量结构-活性关系。人α-胰凝乳蛋白酶也已用于一项研究，以研究使用萃取电喷雾电离质谱法直接检测生物基质中的天然蛋白质。
Biochem/physiol Actions
一种丝氨酸蛋白酶，水解肽键与肽键羧基末端的芳香族或大型疏水侧链（Tyr、Trp、Phe、Met）的肽键。
Analysis Note
由 A1%/280 测定的蛋白质
Other Notes
在pH 7.8、25℃条件下，1个单位将每分钟水解1.0 μmole BTEE。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
常规特殊物品
此项目有
Parallel synthesis of isatin-based serine protease inhibitors
Shuttleworth SJ, et al.
Bioorganic & Medicinal Chemistry Letters, 10(22), 2501-2504 (2000)
Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
Mac Sweeney A, et al.
Acta Crystallographica Section D, Biological Crystallography, 56(3), 280-286 (2000)
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Rosendahl J, et al.
Gut, 67(10), 1855-1863 (2018)
Osvaldo E Sponton et al.
Food chemistry, 146, 577-582 (2013-11-02)
β-Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic ligands, such as retinol, vitamins and fatty acids. Moreover, BLG is susceptible to protease action producing a wide range of polypeptides depending on the hydrolysis
S Yamashita et al.
The British journal of surgery, 100(9), 1220-1228 (2013-06-15)
Pancreatic fistula (PF) remains the most serious complication after digestive surgery. It is difficult to prevent because of the inability to visualize the leakage of pancreatic juice during surgery or to evaluate the protease activity of leaked fluid, which is
实验方案
Follow our procedure for the determination of a chymotrypsin activity. This enzymatic assay of alpha chymotrypsin guides you through the entire process and necessary calculations.
按照我们的程序进行胰凝乳蛋白酶活性测定。该α-胰凝乳蛋白酶测定将会指导您完成整个过程以及必要的计算。
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