D1159
地塞米松-21-磷酸二钠盐 二钠盐
≥98%, Glucocorticoid , powder
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关于此项目
经验公式（希尔记法）:
C22H28FNa2O8P
化学文摘社编号:
分子量:
516.40
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
51422340
EC Number:
219-243-0
MDL number:
Beilstein/REAXYS Number:
6473066
产品名称
地塞米松-21-磷酸二钠盐 二钠盐, ≥98%
Quality Level
assay
≥98%
form
powder
impurities
≤1% ethanol
color
white to off-white
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
InChI
1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
InChI key
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Gene Information
human ... NR3C1(2908)
Application
Dexamethasone 21-phosphate disodium salt has been used:
- as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models
- as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice
- to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs
Biochem/physiol Actions
Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes. It exhibits therapeutic effects against cystic fibrosis and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Effect of operational conditions on the supercritical carbon dioxide impregnation of anti-inflammatory and antibiotic drugs in rigid commercial intraocular lenses
Bouledjouidja A, et al.
Journal of Supercritical Fluids, 130, 63-75 (2017)
Donal T Skelly et al.
Molecular psychiatry, 24(10), 1533-1548 (2018-06-08)
Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these acute events induce injury. Whether systemic inflammation-induced acute dysfunction and acute brain
Kang Ho Kim et al.
Molecular endocrinology (Baltimore, Md.), 30(8), 905-916 (2016-06-30)
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in permanent liver damage. Upon liver damage, nonparenchymal cells
Philip A Bird et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(6), 933-936 (2011-07-05)
To measure dexamethasone concentrations in the plasma and perilymph of the human ear after intravenous (IV) and intratympanic (IT) administration and to compare these with previous studies with methylprednisolone. Patients were administered dexamethasone by the IT or IV routes approximately
Amy E Cohen et al.
Ophthalmology, 119(1), 66-73 (2011-11-26)
Determine safe, effective, iontophoretic dose(s) of EGP-437 (dexamethasone phosphate formulated for iontophoresis) in patients with noninfectious anterior uveitis; evaluate systemic drug exposures. Prospective, phase I/II, multicenter, double-masked, parallel group, randomized clinical trial. Forty outpatients with anterior uveitis. Forty of 42
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1159-500MG | 04061833289303 |
| D1159-100MG | 04061833558874 |
| D1159-1G | 04061833558881 |
| D1159-5G | 04061833558898 |
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