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Merck
CN

D2773

Sigma-Aldrich

地蒽酚

≥90% (HPLC)

别名:

1,8,9-蒽三酚, 1,8-二羟基蒽-9(10H)-酮, 二羟蒽酚, 蒽林

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关于此项目

经验公式(希尔记法):
C14H10O3
化学文摘社编号:
分子量:
226.23
Beilstein:
2054360
EC 号:
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.25
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方案

≥90% (HPLC)

表单

solid

mp

178-181 °C (lit.)

溶解性

chloroform: 20 mg/mL, clear to very slightly hazy, yellow

SMILES字符串

Oc1cccc2Cc3cccc(O)c3C(=O)c12

InChI

1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

InChI key

NUZWLKWWNNJHPT-UHFFFAOYSA-N

基因信息

mouse ... Alox12(11684)

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一般描述

地蒽酚(1,8-二羟基-9-蒽酮)也称为 anthralin。它是一种重要的外用抗牛皮癣药物。地蒽酚是一种蒽衍生物,是一种自由基可产生线粒体毒素,线粒体毒素可诱导角质细胞发生细胞凋亡。

应用

地蒽酚,一种潜在的抗牛皮癣药物,可用于研究其安全性、功效、代谢和药理学特征。地蒽酚可用于研究其物理化学性质,作为一种参考化合物并开发有效的药物运输载体。地蒽酚可用作傅立叶变换离子回旋共振质谱仪上的基质辅助激光解吸/电离成像的基质。

其他说明

为了全面了解我们针对客户研究提供的各种多糖产品,建议您访问我们的碳水化合物分类页面。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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G C Hsieh et al.
Toxicology and applied pharmacology, 107(1), 16-26 (1991-01-01)
Primary cultured rat epidermal keratinocytes were used as an experimental model to detect oxidant-mediated adverse effects of dithranol (anthralin), a widely used antipsoriasis drug with tumor-promoting and skin-irritating properties. Keratinocytes were isolated and prepared from the skin of neonatal rats
Iyad Hailat et al.
Rapid communications in mass spectrometry : RCM, 28(2), 149-158 (2013-12-18)
Free sterols are neutral molecules that are difficult to analyze by MALDI or ESI and their molecular ions easily fragment. In order to increase their ionization efficiency and selectivity, sterols were derivatized by different reagents. Selected sterols were converted into
C Ronpirin et al.
Genetics and molecular research : GMR, 11(1), 412-420 (2012-03-01)
Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in
Kaisar Raza et al.
Journal of microencapsulation, 28(3), 190-199 (2011-03-15)
The objective of this study was to develop and characterize a novel dithranol-containing phospholipid microemulsion systems for enhanced skin permeation and retention. Based on the solubility of dithranol, the selected oils were isopropyl myristate (IPM) and tocopherol acetate (TA), and
Wing Man Lau et al.
Pharmaceutics, 5(2), 232-245 (2013-12-05)
Psoriasis is a common, chronic and relapsing inflammatory skin disease. It affects approximately 2% of the western population and has no cure. Combination therapy for psoriasis often proves more efficacious and better tolerated than monotherapy with a single drug. Combination

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