D2944
抗-D1 多巴胺受体抗体，大鼠单克隆抗体 大鼠抗
clone 1-1-F11 s.E6, purified from hybridoma cell culture
别名:
抗 DRD1
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关于此项目
Conjugate:
unconjugated
Clone:
1-1-F11 s.E6, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, monkey, human
Citations:
60
Technique(s):
immunocytochemistry: 5-10 μg/mL using D1 dopamine receptor transfected HEK-293T cells
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-D1 多巴胺受体抗体，大鼠单克隆抗体 大鼠抗, clone 1-1-F11 s.E6, purified from hybridoma cell culture
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
1-1-F11 s.E6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
rat, monkey, human
concentration
~1 mg/mL
technique(s)
immunocytochemistry: 5-10 μg/mL using D1 dopamine receptor transfected HEK-293T cells
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DRD1(1812)
rat ... Drd1a(24316)
Application
大鼠单克隆抗D1多巴胺受体抗体可用于：
- 免疫组化
- 免疫印迹
- 免疫细胞化学
- 邻位连接检测
- 免疫共沉淀
- 蛋白质印迹
Biochem/physiol Actions
D1 受体调节神经元生长和发育，介导一些行为反应，并调节多巴胺受体D2介导的事件。D1 受体在气道平滑肌（ASM）上表达，通过 cAMP 激活蛋白激酶 A 调节平滑肌张力。它是治疗性 ASM 松弛的潜在靶点。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
D1 多巴胺受体编码多巴胺受体的 D1 亚型。D1 亚型是中枢神经系统中含量最丰富的多巴胺受体。这种 G 蛋白偶联受体刺激腺苷酸环化酶并激活环腺苷酸依赖性蛋白激酶。
单克隆抗D1多巴胺受体（大鼠IgG2a同种型）来源于通过融合小鼠骨髓瘤细胞而杂交瘤1-1-F11 S.E6和使用含人D1多巴胺受体C-端97氨基酸重组融合蛋白免疫大鼠脾细胞。多巴胺受体属于7个跨膜结构域G蛋白偶联受体家族。多巴胺受体主要分布在纹状体、边缘系统、大脑皮层和下丘脑漏斗。D1类家族包括D1受体和D5受体。
Immunogen
含有人多巴胺 D 1 受体 C 末端 97 氨基酸的重组融合蛋白。
Legal Information
根据埃默里大学的独家许可证销售
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Matthieu F Bastide et al.
Scientific reports, 7(1), 2348-2348 (2017-05-26)
A whole brain immediate early gene mapping highlighted the dorsolateral bed nucleus of the stria terminalis (dlBST) as a structure putatively involved in L-3,4-dihydroxyphenylalanine (L-Dopa)-induced dyskinesia (LID), the debilitating side-effects of chronic dopamine replacement therapy in Parkinson's disease (PD). dlBST
D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses
Cahill E, et al.
Molecular Psychiatry, 19(12), 1295-1295 (2014)
Impact of early consumption of high-fat diet on the mesolimbic dopaminergic system
Naneix F, et al.
eNeuro, 4(3) (2017)
Satoshi Goto et al.
Frontiers in neuroanatomy, 9, 22-22 (2015-03-19)
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of
Kentaro Mizuta et al.
Respiratory research, 14, 89-89 (2013-09-06)
Dopamine signaling is mediated by Gs protein-coupled "D1-like" receptors (D1 and D5) and Gi-coupled "D2-like" receptors (D2-4). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the Gi-coupled dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth
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