D3689
(S)-3,5-二羟基苯基甘氨酸 水合物
≥98% (HPLC), group I metabotropic glutamate receptor agonist, powder
别名:
S-DHPG
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关于此项目
经验公式（希尔记法）:
C8H9NO4 · xH2O
化学文摘社编号:
分子量:
183.16 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
产品名称
(S)-3,5-二羟基苯基甘氨酸 水合物, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white
储存温度
−20°C
SMILES字符串
O.N[C@H](C(O)=O)c1cc(O)cc(O)c1
InChI
1S/C8H9NO4.H2O/c9-7(8(12)13)4-1-5(10)3-6(11)2-4;/h1-3,7,10-11H,9H2,(H,12,13);1H2/t7-;/m0./s1
InChI key
QZEFIWWBQUKNFA-FJXQXJEOSA-N
基因信息
human ... GRM1(2911)
相关类别
应用
(S)-3,5-二羟基苯基甘氨酸水合物已被用于：
- 作为mGluR1/5激动剂，在突触神经小体的制备中激活代谢型谷氨酸受体1 (mGluR1/5)
- 用于人工脑脊液 (ACSF) 的DHPG激活
- 注入基底外侧杏仁核，研究其对记忆表达的影响
生化/生理作用
（S）-3，5-二羟基苯基甘氨酸水合物是 I 类代谢型谷氨酸受体激动剂。
特点和优势
该化合物是受体分类及信号转导手册上谷氨酸受体（G蛋白家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
免责声明
空气敏感
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qin-Wei Wu et al.
Frontiers in cell and developmental biology, 8, 569889-569889 (2021-02-09)
Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases which are caused by diverse genetic mutations in a variety of different genes. We have identified RGS8, a regulator of G-protein signaling, as one of the genes which are dysregulated
Infantile amnesia reflects a developmental critical period for hippocampal learning
Travaglia A, et al.
Nature Neuroscience, 19(9), 1225-1225 (2016)
Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression
Majewski L, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1864(6), 1071-1087 (2017)
Enoch Ng et al.
Behavioural brain research, 381, 112420-112420 (2019-12-11)
Neuronal calcium sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal calcium sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder
Katelyn N Benthall et al.
Cell reports, 36(6), 109511-109511 (2021-08-12)
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents with psychiatric conditions, including autism spectrum disorder (ASD). ASD is characterized by restricted, repetitive, and inflexible behaviors, which may result from abnormal activity in striatal circuits that mediate motor
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