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D8375

D-2-脱氧葡萄糖

Name: <SC>D</SC>-2-脱氧葡萄糖
Brand: SIGMA

≥98% (GC), crystalline

别名:

2-脱氧葡萄糖, 2-脱氧-D-葡糖

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关于此项目

经验公式（希尔记法）:

C₆H₁₂O₅

化学文摘社编号:

154-17-6

分子量:

164.16

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

24894205

EC Number:

205-823-0

Beilstein/REAXYS Number:

1723331

MDL number:

MFCD00151328

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biological source

synthetic

Quality Level

200

assay

≥98% (GC)

form

crystalline

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

color

white to off-white

mp

146-147 °C (lit.)

solubility

H₂O: 0.250 g/5mL

application(s)

clinical research
life science and biopharma
metabolomics

storage temp.

2-8°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

InChI

1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

InChI key

VRYALKFFQXWPIH-PBXRRBTRSA-N

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General description

2-脱氧-D-葡萄糖是一种不可代谢的葡萄糖类似物，通过靶向己糖激酶（糖酵解的限速步骤）来破坏糖酵解。它被己糖激酶磷酸化为 2-DG-P，在细胞中积累，消耗细胞 ATP。这种方法可以有效地饿死和杀死癌细胞，也可以抑制依赖糖酵解进行复制的病毒细胞。这种多功能分子可应用于癌症、病毒学、代谢组学和生化研究。

Application

2-脱氧-D-葡萄糖（2-DG）用于缺乏葡萄糖补给的研究，以调用和研究反调节反应（CRR）的过程。2-脱氧-D-葡萄糖用于涉及放射和化学敏化以及氧化应激的抗癌策略开发中。

Biochem/physiol Actions

2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

Features and Benefits

高纯度化合物适用于各种研究应用

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

为了全面了解我们针对客户研究提供的各种单糖产品，建议您访问我们的碳水化合物分类页面。

如需了解生化试剂系列的更多信息，请填写此表。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

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需氧糖酵解和瓦博格效应

本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

全球贸易项目编号

货号	GTIN
D8375-5G	04061833589489
D8375-25G	04061833589472
D8375-100G	04061833589441
D8375-1G	04061833589465
D8375-10MG	04061833589458

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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