产品名称
抗-EN-RAGE 山羊抗, affinity isolated antibody, lyophilized powder
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable (0.25µg/106 cells)
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... S100A12(6283)
Application
山羊产生的抗EN-RAGE抗体适用于工作浓度为0.1-0.2μg/mL的蛋白质印迹分析，浓度为5-15μg/mL的免疫组化，浓度为3-10μg/mL/106个细胞的流式细胞仪。
Biochem/physiol Actions
该基因编码钙，锌和铜结合蛋白，在调节炎症过程和免疫反应中起重要作用。它通过与晚期糖基化终产物受体（AGER）结合来刺激先天免疫细胞，后者激活MAP激酶和NF-κ-B信号通路，从而导致促炎细胞因子的产生以及细胞粘连分子ICAM1和VCAM1的上调。它还刺激肥大细胞脱颗粒和活化，从而产生趋化因子，组胺和细胞因子，白细胞募集到炎症部位。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
EN-RAGE是S100/钙粒蛋白超家族的一员。
Immunogen
纯化的，大肠埃希菌衍生的重组人细胞外RAGE结合蛋白。
Physical form
从含有5％海藻糖的磷酸盐缓冲生理盐水的0.2μm过滤的溶液中冻干。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Zheng Yang et al.
The Journal of allergy and clinical immunology, 119(1), 106-114 (2007-01-09)
The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products. Because inflammation elicited by S100A12 in vivo had characteristics of mast cell (MC) activation, we aimed to define the mechanism. Various MC
Olga V Moroz et al.
BMC biochemistry, 10, 11-11 (2009-04-24)
Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like
Wei Xing Yan et al.
The Journal of biological chemistry, 283(19), 13035-13043 (2008-02-23)
S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain
A M Cole et al.
FEBS letters, 504(1-2), 5-10 (2001-08-28)
The human airways are protected from pathogenic colonization by a blanket of fluid impregnated with innate antimicrobial effector molecules. Among several previously uncharacterized components, we isolated a peptide that had activity primarily targeting Gram-negative bacteria. We named the peptide 'calcitermin'
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持