E2531
抗EPO(红细胞生成素) 兔抗
IgG fraction of antiserum, lyophilized powder
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Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
neutralization
western blot
neutralization
western blot
Species reactivity:
human
Citations:
11
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 1 μg/mL
neutralization: suitable
western blot: 1 μg/mL
Uniprot accession no.:
产品名称
抗EPO(红细胞生成素) 兔抗, IgG fraction of antiserum, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 1 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EPO(2056)
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Application
抗促红细胞生成素抗体可在1μg/ml的工作浓度下用于免疫印迹。对于免疫组织化学，可使用5-15 μg/mL的工作浓度。该抗体还适用于中和反应。促红细胞生成素抗体已被用于表达重组人促红细胞生成素的烟草叶提取物的 ELISA。该抗体还可用于免疫亲和色谱，分离表达重组人促红细胞生成素的烟草叶提取物。
Biochem/physiol Actions
促红细胞生成素 (Epo) 是一种多效性细胞因子，可促进红细胞前体的红细胞生成或增殖和分化。当 Epo 结合并激活 Epo 受体 (EpoR) 二聚体时，会刺激红细胞的产生。EpoR 通过 Jak2、PI3K、NF-κB、STAT5A 和 STAT5B 直接调节信号传导。Epo 还通过下调 Fas（肿瘤坏死因子受体超家族成员 6）和 FasL（Fas 配体）来抑制红系祖细胞的凋亡。 Epo的表达受转录因子缺氧诱导因子（HIF）的控制。 促红细胞生成素具有缓解传染病和慢性炎症性疾病的作用 抗促红细胞生成素抗体可与人促红细胞生成素进行特异性反应。
Disclaimer
除非我们的目录或随附于产品的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Epo 主要由胎儿期肝细胞产生，在缺氧状态下由肾脏产生；肝脏和大脑分泌 Epo 的量也较少。 抗促红细胞生成素抗体与人促红细胞生成素发生特异性反应。 EPO 基因定位于人染色体7q22.1。
Immunogen
CHO 细胞中表达的重组人促红细胞生成素。
Physical form
在含碳水化合物的磷酸盐缓冲盐水中用0.2μm滤过溶液冻干。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Andrew J Conley et al.
Biotechnology and bioengineering, 103(3), 562-573 (2009-03-07)
The demand for recombinant proteins for medical and industrial use is expanding rapidly and plants are now recognized as an efficient, inexpensive means of production. Although the accumulation of recombinant proteins in transgenic plants can be low, we have previously
Molecular definition of a narrow interval at 7q22. 1 associated with myelodysplasia.
Johnson E J, et al.
Blood, 87(9), 3579-3586 (1996)
Farooqahmed S Kittur et al.
Plant cell reports, 31(7), 1233-1243 (2012-03-01)
Erythropoietin (EPO) is a glycoprotein hormone that displays both hematopoietic and tissue-protective functions by binding to two distinct receptors. Recombinant human EPO (rhuEPO) is widely used for the treatment of anemia, but its use for tissue protection is limited because
Andrew J Conley et al.
Plant biotechnology journal, 7(2), 183-199 (2008-12-06)
Human erythropoietin (EPO) is a pleiotropic cytokine with remarkable tissue-protective activities in addition to its well-established role in red blood cell production. Unfortunately, conventional mammalian cell cultures are unlikely to meet the anticipated market demands for recombinant EPO because of
Amit A Joharapurkar et al.
Current research in pharmacology and drug discovery, 3, 100102-100102 (2022-05-17)
Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies. This work assessed the effect of desidustat, an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase
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