E3651
抗-内皮素受体A 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-ET-A, Anti-ET1-Specific Endothelin Receptor
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
8
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, pig, chicken, bovine
technique(s)
immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections, western blot: 1:200 using rat brain membranes and ECL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EDNRA(1909)
rat ... Ednra(24326)
Immunogen
synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).
Application
Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.
The epitope is highly conserved in human, swine, bovine and chicken ET-A.
Physical form
Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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