E7131
[D-Ala2, D-Leu5]-脑啡肽 乙酸盐
≥95% (HPLC)
别名:
DADLE
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关于此项目
经验公式（希尔记法）:
C29H39N5O7
化学文摘社编号:
分子量:
569.65
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Quality Segment
assay
≥95% (HPLC)
storage temp.
−20°C
SMILES string
CC(O)=O.CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C29H39N5O7.C2H4O2/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20;1-2(3)4/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41);1H3,(H,3,4)/t18-,22+,23+,24-;/m1./s1
InChI key
YRZBXSPTRALQEX-IIKZURRYSA-N
Gene Information
human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)
General description
[D-Ala2, D-Leu5]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.
Application
[D-Ala2, D-Leu5]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.
Biochem/physiol Actions
原型 δ-激动剂；比 Leu-脑啡肽和 Met-脑啡肽更强效、更具选择性；镇痛效果与 β-内啡肽相当
Prototypical δ-agonist; more potent and selective than Leu-enkephalin and Met-enkephalin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)