E7131
[D-Ala2, D-Leu5]-脑啡肽 乙酸盐
≥95% (HPLC)
别名:
DADLE
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选择尺寸
关于此项目
经验公式（希尔记法）:
C29H39N5O7
化学文摘社编号:
分子量:
569.65
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
InChI
1S/C29H39N5O7.C2H4O2/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20;1-2(3)4/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41);1H3,(H,3,4)/t18-,22+,23+,24-;/m1./s1
SMILES string
CC(O)=O.CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI key
YRZBXSPTRALQEX-IIKZURRYSA-N
assay
≥95% (HPLC)
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)
General description
[D-Ala2, D-Leu5]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.
Application
[D-Ala2, D-Leu5]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.
Biochem/physiol Actions
原型 δ-激动剂；比 Leu-脑啡肽和 Met-脑啡肽更强效、更具选择性；镇痛效果与 β-内啡肽相当
Prototypical δ-agonist; more potent and selective than Leu-enkephalin and Met-enkephalin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
T P Su
Journal of biomedical science, 7(3), 195-199 (2000-05-16)
By studying the hibernation in ground squirrels, a protein factor termed hibernation induction trigger (HIT) was found to induce hibernation in summer-active ground squirrels. Further purification of HIT yielded an 88-kD peptide that is enriched in winter hibernator. Partial sequence
Danyun Fu et al.
Mediators of inflammation, 2021, 6661620-6661620 (2021-02-26)
Cerebral ischemia-reperfusion (I/R) injury is the main cause of acute brain injury, which is a life-threatening disease due to the lack of effective treatments. [D-Ala2, D-Leu5] enkephalin (DADLE) is a synthetic delta-opioid receptor agonist that is reported to confer neuroprotective
M A Wilson et al.
The Biochemical journal, 325 ( Pt 1), 217-222 (1997-07-01)
The regulation of mitogenic signalling pathways by G-protein-coupled receptors has been studied in Rat-1 fibroblasts stably transfected with the murine delta opioid receptor. We showed recently that stimulation of this receptor led to the activation of the p42 and p44
Yi Zhou et al.
Molecular medicine reports, 16(5), 6214-6221 (2017-09-14)
Hepatic ischemia/reperfusion (I/R) injury is a common pathophysiological process that occurs following liver surgery, which is associated with oxidative stress, and can cause acute liver injury and lead to liver failure. Recently, the development of drugs for the prevention of
L I Tsao et al.
The Journal of pharmacology and experimental therapeutics, 287(1), 322-331 (1998-10-09)
Delta opioid peptide [D-Ala2,D-leu5]enkephalin (DADLE) can prolong organ preservation and increases myocardial tolerance to ischemia. Our study examined the protective property of DADLE against methamphetamine- (METH) induced dopaminergic terminal damage in the central nervous system. Because the neurotoxicity of METH
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