F1016
非诺特罗 氢溴酸盐
adrenoceptor agonist
别名:
2-(3,5-Dihydroxyphenyl)-2-hydroxy-2′-(4-hydroxyphenyl)-1′-methyldiethylamine hydrobromide
产品名称
非诺特罗 氢溴酸盐,
质量水平
创始人
Boehringer Ingelheim
SMILES字符串
Br[H].CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2
InChI
1S/C17H21NO4.BrH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H
InChI key
SGZRQMALQBXAIQ-UHFFFAOYSA-N
基因信息
human ... ADRB2(154)
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一般描述
Fenoterol hydrobromide is a sympathomimetic drug. It is used to treat asthma, bronchitis and emphysema. Fenoterol administration might be linked to liver damage. It has anti-inflammatory effects on eosinophil function.
应用
Fenoterol hydrobromide has been used in chromatography-tandem mass spectrometry (LC&-MS-MS) for specific and sensitive detection of β-agonists (BAG).
生化/生理作用
β2-adrenoceptor agonist; bronchodilator.
特点和优势
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
Lawrence Toll et al.
Molecular pharmacology, 81(6), 846-854 (2012-03-22)
G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components. The detailed interaction of a molecule with a G protein-coupled
Julia J Rucklidge et al.
Human psychopharmacology, 27(5), 440-454 (2012-07-12)
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Inhibition by fenoterol of human eosinophil functions including beta2-adrenoceptor-independent actions
Tachibana A, et al.
Clinical and Experimental Immunology, 130(3), 415-423 (2002)
Hegui Wang et al.
PloS one, 7(9), e46186-e46186 (2012-10-03)
Increasing evidence indicates that the rapid component of delayed rectifier potassium current (I(Kr)) is modulated by α- and β-adrenergic stimulation. However, the role and mechanism regulating I(Kr) through β(2)-adrenoreceptor (β-AR) stimulation in heart failure (HF) are unclear. In the present
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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 22(4), 431-439 (2011-02-16)
Short-acting β2-adrenoreceptor agonist (SABA) is the major asthma reliever as indicated in the GINA guidelines. Regulated on activation, normal T expressed and secreted (RANTES) is a chemokine that attracts eosinophils, mast cells, and basophils toward site of allergic inflammation. Interferon
Chromatograms
application for HPLC
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