F1016
非诺特罗 氢溴酸盐
adrenoceptor agonist
别名:
2-(3,5-Dihydroxyphenyl)-2-hydroxy-2′-(4-hydroxyphenyl)-1′-methyldiethylamine hydrobromide
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关于此项目
经验公式（希尔记法）:
C17H21NO4 · HBr
化学文摘社编号:
分子量:
384.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
217-742-8
MDL number:
Quality level:
产品名称
非诺特罗 氢溴酸盐,
Quality Level
originator
Boehringer Ingelheim
SMILES string
Br[H].CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2
InChI
1S/C17H21NO4.BrH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H
InChI key
SGZRQMALQBXAIQ-UHFFFAOYSA-N
Gene Information
human ... ADRB2(154)
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General description
Fenoterol hydrobromide is a sympathomimetic drug. It is used to treat asthma, bronchitis and emphysema. Fenoterol administration might be linked to liver damage. It has anti-inflammatory effects on eosinophil function.
Application
Fenoterol hydrobromide has been used in chromatography-tandem mass spectrometry (LC&-MS-MS) for specific and sensitive detection of β-agonists (BAG).
Biochem/physiol Actions
β2-adrenoceptor agonist; bronchodilator.
Features and Benefits
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
Dorota Latek et al.
Journal of molecular modeling, 17(9), 2353-2366 (2011-03-03)
Cannabinoid and adrenergic receptors belong to the class A (similar to rhodopsin) G protein coupled receptors. Docking of agonists and antagonists to CB(1) and CB(2) cannabinoid receptors revealed the importance of a centrally located rotamer toggle switch and its possible
Oxford Dictionary of Medicines, Jan Hawthorn, 2003: Oxford Dictionary of Medicines (2003)
Rajib K Paul et al.
The Journal of pharmacology and experimental therapeutics, 343(1), 157-166 (2012-07-11)
Inhibition of cell proliferation by fenoterol and fenoterol derivatives in 1321N1 astrocytoma cells is consistent with β(2)-adrenergic receptor (β(2)-AR) stimulation. However, the events that result in fenoterol-mediated control of cell proliferation in other cell types are not clear. Here, we
Bart G J Dekkers et al.
The Journal of pharmacology and experimental therapeutics, 342(3), 780-787 (2012-06-12)
Airway remodeling, including increased airway smooth muscle (ASM) mass and contractility, contributes to increased airway narrowing in asthma. Increased ASM mass may be caused by exposure to mitogens, including platelet-derived growth factor (PDGF) and collagen type I, which induce a
Lawrence Toll et al.
Molecular pharmacology, 81(6), 846-854 (2012-03-22)
G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components. The detailed interaction of a molecule with a G protein-coupled
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F1016-1G | 04061833611562 |
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