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F3418

Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse

Name: Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse
Brand: SIGMA

clone C-11, purified immunoglobulin, buffered aqueous solution

别名:

Monoclonal Anti-Pan Cytokeratin

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

FITC conjugate

Clone:

C-11, monoclonal

Application:

IF (d), IHC (p), WB

Citations:

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biological source

mouse

Quality Level

200

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C-11, monoclonal

form

buffered aqueous solution

species reactivity

bovine, mouse, frog, human, kangaroo rat, rat

storage condition

protect from light

technique(s)

direct immunofluorescence: 1:50 using PtK₂ cells, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using human placenta, western blot: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Cytokeratins are the intermediate filaments of endocrine cells. These proteins belong to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratins are the largest and most complex group of intermediate filaments. The family consists of at least 30 proteins with molecular weights ranging from 40kDa to 68kDa.

Immunogen

keratin-enriched preparation from cultured human epidermoid carcinoma cell line A431.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Monoclonal Anti-Cytokeratin, pan−FITC antibody has been used in immunocytochemistry and has also been used to visualize lung epithelial cells.

Biochem/physiol Actions

Cytokeratins helps in subtyping several kinds of epithelial differentiation or for narrowing possible sites of origin for metastatic carcinomas. Cytokeratins may play an important role in transhepatic transport and canalicular secretion.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

低风险生物材料

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.

Ingunn M Stromnes et al.

Cancer immunology research, 5(11), 978-991 (2017-10-27)

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to most therapies, including immune checkpoint blockade. To elucidate mechanisms of immunotherapy resistance, we assessed immune parameters in resected human PDA. We demonstrate significant interpatient variability in T-cell number, localization, and

Flavonoids from Engineered Tomatoes Inhibit Gut Barrier Pro-inflammatory Cytokines and Chemokines, via SAPK/JNK and p38 MAPK Pathways.

Matthew L Tomlinson et al.

Frontiers in nutrition, 4, 61-61 (2018-01-13)

Flavonoids are a diverse group of plant secondary metabolites, known to reduce inflammatory bowel disease symptoms. How they achieve this is largely unknown. Our study focuses on the gut epithelium as it receives high topological doses of dietary constituents, maintains

Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study.

C J Morrow et al.

Annals of oncology : official journal of the European Society for Medical Oncology, 27(6), 1155-1160 (2016-03-26)

Over the past decade, numerous reports describe the generation and increasing utility of non-small-cell lung cancer (NSCLC) patient-derived xenografts (PDX) from tissue biopsies. While PDX have proven useful for genetic profiling and preclinical drug testing, the requirement of a tissue

Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages

Januzi L, et al.

Cellular Immunology, 332(2), 7-23 (2018)

Potential biological role of transforming growth factor-beta in human congenital kidney malformations

Yang Su P, et al.

The American Journal of Pathology, 157(5), 1633-1647 (2000)

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全球贸易项目编号

货号	GTIN
F3418-.5ML	04061838163424
F3418-.2ML	04061838105226

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