F6627
5-氟脲嘧啶
≥99% purity (HPLC), powder
别名:
2,4-二羟基-5-氟嘧啶, 5-FU, 5-氟-2,4(1H,3H)-嘧啶二酮
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关于此项目
经验公式（希尔记法）:
C4H3FN2O2
化学文摘社编号:
分子量:
130.08
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
200-085-6
MDL number:
Beilstein/REAXYS Number:
127172
产品名称
5-氟脲嘧啶, ≥99% (HPLC), powder
Quality Segment
assay
≥99% (HPLC)
form
powder
technique(s)
titration: suitable
color
white
mp
282-286 °C (dec.) (lit.)
solubility
1 M NH4OH: soluble, DMSO/DMF: soluble, methanol: soluble
εmax
7.07 at 265 nm in 0.1 M HCl
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
Gene Information
human ... TYMS(7298)
Application
5-氟尿嘧啶被用于诱导细胞凋亡。它被用作化学增敏剂。
Biochem/physiol Actions
一种有效的抗肿瘤药物，通过抑制胸苷酯合成酶来影响嘧啶的合成，从而耗尽细胞内的dTTP池。其代谢产物为核糖核酸和脱氧核糖核酸，可与RNA和DNA结合。用5-FU处理细胞可导致细胞在S-期积累，并已被证明其可诱导p53依赖的凋亡。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3