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F6627

5-氟脲嘧啶

Name: 5-氟脲嘧啶
Brand: SIGMA

≥99% purity (HPLC), powder

别名:

2,4-二羟基-5-氟嘧啶, 5-FU, 5-氟-2,4(1H,3H)-嘧啶二酮

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关于此项目

经验公式（希尔记法）:

C₄H₃FN₂O₂

化学文摘社编号:

51-21-8

分子量:

130.08

NACRES:

NA.47

PubChem Substance ID:

24278439

UNSPSC Code:

12171500

EC Number:

200-085-6

MDL number:

MFCD00006018

Beilstein/REAXYS Number:

127172

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产品名称

5-氟脲嘧啶, ≥99% (HPLC), powder

Quality Level

200

assay

≥99% (HPLC)

form

powder

technique(s)

titration: suitable

color

white

mp

282-286 °C (dec.) (lit.)

solubility

1 M NH4OH: soluble, DMSO/DMF: soluble, methanol: soluble

ε_max

7.07 at 265 nm in 0.1 M HCl

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

Gene Information

human ... TYMS(7298)

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Application

5-氟尿嘧啶被用于诱导细胞凋亡。它被用作化学增敏剂。

Biochem/physiol Actions

一种有效的抗肿瘤药物，通过抑制胸苷酯合成酶来影响嘧啶的合成，从而耗尽细胞内的dTTP池。其代谢产物为核糖核酸和脱氧核糖核酸，可与RNA和DNA结合。用5-FU处理细胞可导致细胞在S-期积累，并已被证明其可诱导p53依赖的凋亡。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Handbook of Drug Nutrient Interactions Nutrition and Health (2004)

Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II.

Jiang JX

Molecular Medicine Reports, 10, 995-995 (2014)

Coulson CJ

Molecular Mechanisms Of Drug Action (1994)

Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma.

Hartojo W

Translational Oncology, 3, 99-99 (2010)

CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms.

Fang WB et al.

The Journal of Biological Chemistry, 287, 36593-36593 (2012)

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全球贸易项目编号

货号	GTIN
F6627-5G	04061835347698
F6627-1G	04061835347681
F6627-10G	04061835347674

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