F7053
抗 纽蛋白 −小鼠单克隆 FITC 抗体
clone hVIN-1, purified from hybridoma cell culture
别名:
黏着斑蛋白单克隆抗体 小鼠抗
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关于此项目
Conjugate:
FITC conjugate
Clone:
hVIN-1, monoclonal
Application:
direct immunofluorescence
Species reactivity:
frog, chicken, mouse, canine, human, bovine, rat, turkey
Citations:
18
Technique(s):
direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells
Uniprot accession no.:
产品名称
抗 纽蛋白 −小鼠单克隆 FITC 抗体, clone hVIN-1, purified from hybridoma cell culture
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
hVIN-1, monoclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
frog, chicken, mouse, canine, human, bovine, rat, turkey
storage condition
protect from light
technique(s)
direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VCL(7414)
mouse ... Vcl(22330)
rat ... Vcl(305679)
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Application
抗黏着斑蛋白-FITC单克隆抗体适用于成纤维细胞的免疫荧光染色，以研究纳米纤维空间组织对细胞行为的影响。它还适用于使用甲醇/丙酮固定培养的牛 MDBK 细胞（1:50 稀释）进行直接免疫荧光。
Biochem/physiol Actions
特异性标记细胞间和细胞-基质连接处的黏着斑蛋白。与人黏着斑蛋白反应强烈。与平滑肌黏着斑蛋白剪切变体metavinculin具有交叉反应性。
纽蛋白是一种细胞骨架蛋白，分子量约为 116 kDa。纽蛋白与粘附膜区域密切相关，例如黏着斑、足体或黏着小带类细胞间连接。它充当整合素和肌动蛋白细胞骨架相互作用的介质。它在整合素、细胞表面 ECM 分子受体和 F-肌动蛋白细胞骨架之间架起一座桥梁。它与踝蛋白和α-肌动蛋白相关，后者直接与整合素连接。在黏着斑装配过程中，黏着斑蛋白还与α-连环蛋白和血管扩张剂刺激磷蛋白（VASP）结合。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
来自子宫的纯化人黏着斑蛋白。
Physical form
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Akiko Hashimoto-Tane et al.
The Journal of experimental medicine, 213(8), 1609-1625 (2016-06-30)
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cells represents a hallmark of initiation of acquired immunity. T cell activation is initiated at T cell receptor (TCR) microclusters (MCs), in which TCRs and signaling molecules
Mathieu Maalouf et al.
Nanomaterials (Basel, Switzerland), 12(10) (2022-05-29)
Ultrashort pulse lasers have significant advantages over conventional continuous wave and long pulse lasers for the texturing of metallic surfaces, especially for nanoscale surface structure patterning. Furthermore, ultrafast laser beam polarization allows for the precise control of the spatial alignment
Viorel-Iulian Suica et al.
Proteome science, 13, 30-30 (2015-12-03)
Membrane microdomains represent dynamic membrane nano-assemblies enriched in signaling molecules suggesting their active involvement in not only physiological but also pathological molecular processes. The hyperlipidemic stress is a major risk factor of atherosclerosis, but its exact mechanisms of action at
Carol Jurchenko et al.
Biophysical journal, 106(7), 1436-1446 (2014-04-08)
The interplay between chemical and mechanical signals plays an important role in cell biology, and integrin receptors are the primary molecules involved in sensing and transducing external mechanical cues. We used integrin-specific probes in molecular tension fluorescence microscopy to investigate
A Westmeyer et al.
The EMBO journal, 9(7), 2071-2078 (1990-07-01)
We have analyzed the functional domain structure of vinculin, a protein involved in linking microfilaments to the cytoplasmic face of cell membranes in animal cells. For this purpose, we used several monoclonal antibodies raised against chicken gizzard vinculin whose epitopes
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